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3-Carbamoymethyl-5-methylhexanoic acid

3-Carbamoymethyl-5-methylhexanoic acid structure

CAS No.: 181289-15-6

Chemical Name:: 3-Carbamoymethyl-5-methylhexanoic acid

Synonyms: 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid;Pregabalin intermediate;Isobutylglutarmonoamide;rac-Pregabalin Impurity III;Pregabalin 3-Carbamoylmethyl Racemate;3-(2-Amino-2-oxoethyl)-5-methylhexanoic;3-(Carbamoylmethyi-5-methyl hexanoic acid;3-Carbamoymethyl-5-methylhexanoic acid: 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid;3-Carbamoymethyl-5-m;（3-(2-Amino-2-oxoethyl)-5-

CBNumber:: CB3854798

Molecular Formula:: C9H17NO3

Molecular Weight:: 187.24

MDL Number:: MFCD08457698

MOL File:: 181289-15-6.mol

MSDS File:: SDS

Last updated:2026-06-19 07:28:27

Product description	Number	Pack Size	Price
3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid	A3287	25G	$25
3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid	A3287	100G	$57
3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	AA0022PF	25g	$10
3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	AA0022PF	100g	$24
3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	AA0022PF	500g	$114
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3-Carbamoymethyl-5-methylhexanoic acid Properties

Melting point	106-108°C
Boiling point	401.9±28.0 °C(Predicted)
Density	1.080±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	4.68±0.10(Predicted)
color	White to Off-White
Major Application	pharmaceutical small molecule
InChI	InChI=1S/C9H17NO3/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H2,10,11)(H,12,13)
InChIKey	NPDKTSLVWGFPQG-UHFFFAOYSA-N
SMILES	C(O)(=O)CC(CC(N)=O)CC(C)C
CAS DataBase Reference	181289-15-6(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P261-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338
WGK Germany	WGK 3
HS Code	2924.19.8000
Storage Class	11 - Combustible Solids
Hazard Classifications	Skin Irrit. 2

3-Carbamoymethyl-5-methylhexanoic acid price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A3287	3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid	181289-15-6	25G	$25	2026-04-30	Buy
TCI Chemical	A3287	3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid	181289-15-6	100G	$57	2026-04-30	Buy
aablocks	AA0022PF	3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	181289-15-6	25g	$10	2026-05-28	Buy
aablocks	AA0022PF	3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	181289-15-6	100g	$24	2026-05-28	Buy
aablocks	AA0022PF	3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid ≥98%	181289-15-6	500g	$114	2026-05-28	Buy

Product number	Packaging	Price	Buy
A3287	25G	$25	Buy
A3287	100G	$57	Buy
AA0022PF	25g	$10	Buy
AA0022PF	100g	$24	Buy
AA0022PF	500g	$114	Buy

3-Carbamoymethyl-5-methylhexanoic acid Chemical Properties,Uses,Production

Physical Form

Powder

Uses

3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid is a Pregabalin, a GABA analogue used as an anticonvulsant, intermediate.

Uses

3-(2-Amino-2-oxoethyl)-5-methylhexanoic Acid is a Pregabalin (P704800), a GABA analogue used as an anticonvulsant, intermediate.

Synthesis

185815-59-2

181289-15-6

The general procedure for the synthesis of 3-(aminocarbonylmethyl)-5-methylhexanoic acid using 4-isobutyldihydro-2H-pyran-2,6(3H)-dione as a starting material was as follows: first, 70 g of the dried product of 3-isobutylglutaric acid was reacted with 70 g of acetic anhydride at 120 °C for 2 h to produce 3-isobutylglutaric anhydride. Subsequently, 75g of 3-isobutylglutaric anhydride solution was slowly added dropwise to 180g of ammonia, and the temperature was controlled at 10°C during the reaction. After the dropwise addition, the reaction was continued for 2 hours. After the completion of the reaction, the pH of the solution was adjusted to 2~3 with hydrochloric acid, and a white powdery solid was obtained by filtration, i.e., the target product 3-isobutylglutaric acid monoamide. Liquid phase detection of the product showed a purity of 99.8%, a yield of 95% and an overall yield of 77.5%. Figure 4 illustrates the liquid phase assay results of 3-isobutylglutaric acid monoamide.

References

[1] Patent: CN106278931, 2017, A. Location in patent: Paragraph 0038; 0039; 0040
[2] Patent: WO2012/93411, 2012, A2. Location in patent: Page/Page column 18-19
[3] Patent: WO2009/4643, 2009, A2. Location in patent: Page/Page column 26
[4] Organic Process Research and Development, 2009, vol. 13, # 4, p. 812 - 814

3-Carbamoymethyl-5-methylhexanoic acid synthesis

Synthesis of 3-Carbamoymethyl-5-methylhexanoic acid from 3-isobutylglutaric anhydride

3-Carbamoymethyl-5-methylhexanoic acid Preparation Products And Raw materials

Raw materials

3-isobutylglutaric acid Pentanedioic acid, 3-(2-methylpropyl)-, 1-[1-(1-naphthalenyl)ethyl] ester 3-isobutylglutaric anhydride

Preparation Products

Hexanoicacid, 3-(2-amino-2-oxoethyl)-5-methyl-, (3S)- (R)-(-)-3-Carbamoymethyl-5-methylhexanoic acid

3-Carbamoymethyl-5-methylhexanoic acid Suppliers

Global( 353)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5220	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20120	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +86-15383190639	admin@86-ss.com	China	999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from 3-Carbamoymethyl-5-methylhexanoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-29	3-Carbamoymethyl-5-methylhexanoic acid 181289-15-6			0.99		RongNa Biotechnology Co.,Ltd
2026-07-28	3-Carbamoymethyl-5-methylhexanoic acid 181289-15-6	$800.00-999.00	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-07-09	3-Carbamoymethyl-5-methylhexanoic acid 181289-15-6	$1.20-35.00	1kg	99%		Henan Fengda Chemical Co., Ltd

3-Carbamoymethyl-5-methylhexanoic acid
181289-15-6
0.99
RongNa Biotechnology Co.,Ltd

3-Carbamoymethyl-5-methylhexanoic acid
181289-15-6
$800.00-999.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

3-Carbamoymethyl-5-methylhexanoic acid
181289-15-6
$1.20-35.00
99%
Henan Fengda Chemical Co., Ltd

3-Carbamoymethyl-5-methylhexanoic acid Spectrum

3-Carbamoymethyl-5-methylhexanoic acid(181289-15-6)¹HNMR

181289-15-6(3-Carbamoymethyl-5-methylhexanoic acid)Related Search:

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3-(Aminomethyl)-5-methylhexanoic acid (r)-(-)-3-carbamoymethyl-5-methylhexanoic acid 3-Carbamoymethyl-5-methylhexanoic acid

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3-Carbamoymethyl-5-methylhexanoic acid 3-Carbamoymethyl-5-methylhexanoic acid (Pregabalin) ()-3-(AMIOMETHYL)-5-METHYLHEXANOIC ACID 3-Carbamoymethyl-5-m 3-(Carbamoylmethyi-5-methyl hexanoic acid (2-aMino-2-oxoethyl)-5-Methylhexanoic acid Pregabalin intermediate Hexanoic acid, 3-(2-aMino-2-oxoethyl)-5-Methyl- 3-Carbamoylmethyl-5-hexanoic acid 3-Carbamoymethyl-5-methylhexanoic acid: 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid (3S)-3-(2-Amino-2-oxo-ethyl)-5-methyl-hexanoic acid 3-(2-Amino-2-oxoethyl)-5-methylhexanoic (+-)-3-(Carbomoyl methyl)-5-methyl Hexanoic Acid rac-Pregabalin Impurity III 3-(2-Amino-2-Oxoethyl)-5-Methylhexanoic Acid 3 Pregabalin impurity 5/3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid Pregabalin Isobutyl glutarmonoamide Pregabalin 3-Carbamoylmethyl Racemate 3-(2-amino-2-oxoethyl)-5-methylhexanoicaci PREGABALINS INTERMEDIATES 02 3-Carbamoymethyl-5-methylhexanoic acid ISO 9001：2015 REACH Pregabalin intermediate(Widely Superior products) （3-(2-Amino-2-oxoethyl)-5- (+-)3-(Cabomoyl methyl)-5-methyl hexanoic Acid (+/-)-3-Carbamoylmethyl 5-methyl hexanoic acid(CMH) 3-(CARBAMOYLMETHYL)-5- METHYLHEXANOIC ACID (CMH) (R,S)-3-(Carbamoylmethyl)-5-methylHexanoic acid (CMH) (or) 3-(2-amino-2-oxoethyl)-5-methylhexanoic acid PREGABALIN CMH/3-(2-AMINO-2-OXOETHYL)-5-METHYLHEXANOIC ACID 3-\u200b(2-\u200bAmino-\u200b2-\u200boxoethyl)\u200b-\u200b5-\u200bmethylhexanoic Acid Pregabalin Impurity (RS-CMH acid) (±)-3-(Aminocarbonylmethyl)-5-methylhexanoic acid (±)-3-(Carbamoylmethyl)-5-methylhexanoicacid rac-Pregabalin Impurity III (rac-Pregabalin Impurity 94) 3-Carbamoymethyl-5-methylhexanoic acid 99% rac-Pregabalin Impurity 94 3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid Isobutylglutarmonoamide 181289-15-6 13092-52-6 APIs Intermediate intermidiate of Pregablin Pharmaceutical material and intermeidates