Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
![Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]- Structure](CAS/20240320/GIF/3037332-85-4.gif)
- CAS No.
- 3037332-85-4
- Chemical Name:
- Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
- Synonyms
- MS-II-124;Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
- CBNumber:
- CB714686116
- Molecular Formula:
- C28H28ClFN2O4S
- Molecular Weight:
- 543.05
- MDL Number:
- MOL File:
- 3037332-85-4.mol
- MSDS File:
- SDS
Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1173332 | MS-II-124 99.66% | 3037332-85-4 | 5mg | $141 | 2026-06-04 | Buy |
| ChemScene | CS-1173332 | MS-II-124 99.66% | 3037332-85-4 | 10mg | $227 | 2026-06-04 | Buy |
| ChemScene | CS-1173332 | MS-II-124 99.66% | 3037332-85-4 | 25mg | $455 | 2026-06-04 | Buy |
| ChemScene | CS-1173332 | MS-II-124 99.66% | 3037332-85-4 | 50mg | $731 | 2026-06-04 | Buy |
| ChemScene | CS-1173332 | MS-II-124 99.66% | 3037332-85-4 | 100mg | $1170 | 2026-06-04 | Buy |
Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]- Chemical Properties, Uses, Production
Uses
MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[1].
in vivo
MS-II-124 (10 mg/kg; i.p.; single dose) reduces lung inflammation and immune cell infiltration in the LPS (HY-D1056) ( i.n. instillation, 40 μg in 40 μL PBS) -induced ALI/ARDS wild-type mouse model, exhibiting anti-inflammatory and immunomodulatory activities[1].
| Animal Model: | ALI/ARDS WT C57BL/6 mice model[1]. |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS). |
| Result: | Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production. |
References
[1] Xu Y, et al. Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury[J]. Bioorganic Chemistry, 2024: 107562. DOI:10.1016/j.bioorg.2024.107562
Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| Guangzhou Younan Technology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
