ChemicalBook >> CAS DataBase List >>2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- structure

CAS No.: 3033018-68-4

Chemical Name:: 2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-

Synonyms: BRD9 Degrader-2;Amphista Therapeutics' BRD9 Degrader (Compound B11);2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-

CBNumber:: CB714686176

Molecular Formula:: C40H43F3N6O4S

Molecular Weight:: 760.87

MDL Number:

MOL File:: 3033018-68-4.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

Request For Quotation

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Properties

Boiling point	856.3±75.0 °C(predicted)
Density	1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	6.66±0.10(predicted)

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Chemical Properties,Uses,Production

Uses

BRD9 Degrader-2 (Compound B11) is a BRD9 degrader (DC50 ≤1.25 nM; Dmax≥75%). BRD9 Degrader-2 can be used for research of cancers[1].

IC 50

BRD9: <1.25 nM (DC₅₀)

References

[1] David MCGARRY, et al. Compounds for targeted protein degradation. Patent. WO2024057021A1

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Preparation Products And Raw materials

Raw materials

Preparation Products

2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
ChemOrigin Pharm	15026428026 19002516454	ChemOrigin@126.com	China	1581	58

Supplier	Advantage
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
ChemOrigin Pharm	58

3033018-68-4(2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]-)Related Search:

UBA1 Protein, Human (sf9, His-GST) UBA5 Protein, Human (His) UBE2A Protein, Human (GST-His) WWP2 Protein, Human (sf9, His-GST) Thalidomide

AU-15330

1of2