2-(4-BROMO-PHENYL)-PYRROLIDINE
- CAS No.
- 383127-22-8
- Chemical Name:
- 2-(4-BROMO-PHENYL)-PYRROLIDINE
- Synonyms
- MFCD11506298;AKOS BB-8866;2-(4-bromophenyl)-pyrolidine;2-(4-BROMO-PHENYL)-PYRROLIDINE;Pyrrolidine, 2-(4-bromophenyl)-;4-(Pyrrolidin-3-yl)bromobenzene;2-(4-Bromo-phenyl)-pyrrolidine 97%;1-Bromo-4-(pyrrolidin-2-yl)benzene;2-(4-BROMOPHENYL)PYRROLIDINE HYDROCHLORIDE;tert-butyl 3-allyl-3-hydroxyazetidine-10-carboxylate
- CBNumber:
- CB7148677
- Molecular Formula:
- C10H12BrN
- Molecular Weight:
- 226.11
- MDL Number:
- MFCD02663432
- MOL File:
- 383127-22-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 287.2±33.0 °C(Predicted) |
|---|---|
| Density | 1.369±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.58±0.10(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C10H12BrN/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h3-6,10,12H,1-2,7H2 |
| InChIKey | HIJZBROSVFKSCP-UHFFFAOYSA-N |
| SMILES | N1CCCC1C1=CC=C(Br)C=C1 |
| CAS DataBase Reference | 383127-22-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
| HS Code | 2933998090 |
2-(4-BROMO-PHENYL)-PYRROLIDINE price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6495 | 2-(4-Bromophenyl)pyrrolidine min. 95.0 % | 383127-22-8 | 200MG | $43 | 2026-04-30 | Buy |
| TCI Chemical | B6495 | 2-(4-Bromophenyl)pyrrolidine min. 95.0 % | 383127-22-8 | 1G | $130 | 2026-04-30 | Buy |
| Usbiological | 265693 | 2-(4-Bromophenyl)pyrrolidine Asreported | 383127-22-8 | 250mg | $347 | 2026-06-03 | Buy |
| Usbiological | 265693 | 2-(4-Bromophenyl)pyrrolidine Asreported | 383127-22-8 | 500mg | $475 | 2026-06-03 | Buy |
| Usbiological | 265693 | 2-(4-Bromophenyl)pyrrolidine Asreported | 383127-22-8 | 1g | $818 | 2026-06-03 | Buy |
2-(4-BROMO-PHENYL)-PYRROLIDINE Chemical Properties,Uses,Production
Synthesis
22217-79-4
383127-22-8
General procedure for the synthesis of 2-(4-bromophenyl)-pyrrolidine from 5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole: NaBH4 (1.52 g, 40 mmol) was added to 5-(4-bromophenyl)-3,4-dihydro-2H-pyrrole (4.48 g, 20 mmol) dissolved in a H2O/MeOH (30 mL, v /v 1:4) solution. The reaction mixture was stirred for 4 hours and then slowly warmed up to room temperature. After the completion of the reaction was monitored by TLC, 2N HCl was added to quench the unreacted NaBH4. Subsequently, the organic and aqueous layers were separated by diluting the reaction mixture with deionized water and ether. The aqueous layer was further extracted with ether and the combined organic phases were adjusted to pH 12-13 with 4 M NaOH and washed with ethyl acetate. All organic extracts were combined, washed with saturated brine and dried over anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give the crude product 2-(4-bromophenyl)-pyrrolidine as a yellow oil (3.8 g, 84% yield), which could be used in the subsequent reaction without further purification.LC-MS (ESI) m/z: 226 (M + 1)+.
References
[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 99
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 196
[3] Journal of Organic Chemistry, 2005, vol. 70, # 9, p. 3705 - 3708
[4] Patent: WO2008/70447, 2008, A2. Location in patent: Page/Page column 49
[5] Patent: WO2009/112565, 2009, A1. Location in patent: Page/Page column 42
2-(4-BROMO-PHENYL)-PYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Fei Yan Chemical Technology Co., Ltd. | 021-34663897 13816465839 | 1141976404@qq.com | China | 41 | 57 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai ZaiQi Bio-Tech Co., Ltd. | 021-54824098, 021-37212705 021-37212706, 13391256916 | sales@chemzq.com | China | 569 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Lastest Price from 2-(4-BROMO-PHENYL)-PYRROLIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 2-(4-BROMO-PHENYL)-PYRROLIDINE
383127-22-8
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 2-(4-BROMO-PHENYL)-PYRROLIDINE
383127-22-8
- $9.80
- ≥99%
- Career Henan Chemical Co
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