5,7-Dichloroimidazo[4,5-b]pyridine
![5,7-Dichloroimidazo[4,5-b]pyridine Structure](CAS/GIF/24485-01-6.gif)
- CAS No.
- 24485-01-6
- Chemical Name:
- 5,7-Dichloroimidazo[4,5-b]pyridine
- Synonyms
- Nsc264046;7-dichloro-1H-iMidazo[4;5,7-Dichloroimidazo[4,5-b]pyridine;5,7-dichloro-1H-imidazo[4,5-b]pyridine;Dichloro-1H-imidazolo [4,5-b] pyridine;5,7-dichloro-7aH-imidazo[4,5-b]pyridine;3H-Imidazo[4,5-b]pyridine, 5,7-dichloro-;1H-IMidazo[4,5-b]pyridine, 5,7-dichloro-;(1)5,7-dichloro-3H-imidazo[4,5-b]pyridine
- CBNumber:
- CB71509244
- Molecular Formula:
- C6H3Cl2N3
- Molecular Weight:
- 188.01
- MDL Number:
- MFCD11111407
- MOL File:
- 24485-01-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5,7-Dichloro-1H-imidazo[4,5-b]pyridine | D436853 | 500mg | $175 |
| 5,7-Dichloro-3H-imidazo[4,5-b]pyridine | J96722 | 1g | $190 |
| 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 96% | 3H32-5-NF | 250mg | $208 |
| 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 96% | OR931839 | 1g | $235 |
| 5,7-Dichloro-1H-imidazo[4,5-b]pyridine | FD139433 | 1g | $240 |
| More product size | |||
| Melting point | 273-274 °C |
|---|---|
| Boiling point | 200.8±50.0 °C(Predicted) |
| Density | 1.79±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 5.37±0.40(Predicted) |
| Appearance | Off-white to pink Solid |
| InChI | InChI=1S/C6H3Cl2N3/c7-3-1-4(8)11-6-5(3)9-2-10-6/h1-2H,(H,9,10,11) |
| InChIKey | IKJFWUNKUZVHGU-UHFFFAOYSA-N |
| SMILES | C12NC=NC1=C(Cl)C=C(Cl)N=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933998090 |
5,7-Dichloroimidazo[4,5-b]pyridine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D436853 | 5,7-Dichloro-1H-imidazo[4,5-b]pyridine | 24485-01-6 | 500mg | $175 | 2021-12-16 | Buy |
| AK Scientific | J96722 | 5,7-Dichloro-3H-imidazo[4,5-b]pyridine | 24485-01-6 | 1g | $190 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-5-NF | 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 96% | 24485-01-6 | 250mg | $208 | 2021-12-16 | Buy |
| Apolloscientific | OR931839 | 5,7-Dichloro-1H-imidazo[4,5-b]pyridine 96% | 24485-01-6 | 1g | $235 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139433 | 5,7-Dichloro-1H-imidazo[4,5-b]pyridine | 24485-01-6 | 1g | $240 | 2021-12-16 | Buy |
5,7-Dichloroimidazo[4,5-b]pyridine Chemical Properties,Uses,Production
Synthesis
![3H-Imidazo[4,5-b]pyridine, 7-nitro-, 4-oxide](/CAS/GIF/14432-11-2.gif)
14432-11-2
![5,7-Dichloroimidazo[4,5-b]pyridine](/CAS/GIF/24485-01-6.gif)
24485-01-6
General procedure for the synthesis of 5,7-dichloro-1H-imidazo[4,5-B]pyridine from 7-nitro-3H-imidazo[4,5-B]pyridine 4-oxide: 7-nitro-1H-imidazo[4,5-b]pyridine 4-oxide (2.0 g, 11.04 mmol) was added batchwise to a mixed solution of ice-bath-cooled (0 °C) phosphoryl chloride (POCl3, 30 mL , 322 mmol) and N,N-dimethylformamide (DMF, 15 mL) in a mixed solution. Subsequently, the reaction mixture was heated to 120°C and maintained for 3 hours. After completion of the reaction, it was cooled to room temperature, slowly poured into ice water and neutralized with 5 M sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (3 × 75 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the crude product 5,7-dichloro-3H-imidazo[4,5-b]pyridine (1.86 g, 9.89 mmol, 90% yield), which was used directly in the next reaction without further purification. Mass spectrum (electrospray ionization) m/e 188 ([M+H]+). 1H NMR (400 MHz, methanol-d4) δ 8.45 (broad single peak, 1H), 7.46 (single peak, 1H).
References
[1] Patent: WO2013/95761, 2013, A1. Location in patent: Page/Page column 32; 33; 34
[2] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, # 8, p. 1757 - 1760
5,7-Dichloroimidazo[4,5-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1262 | 58 |
View Lastest Price from 5,7-Dichloroimidazo[4,5-b]pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![3H-Imidazo[4,5-b]pyridine, 5,7-dichloro- pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/094404a6-9a60-4d33-bc1b-b3550f14dbc7.png) |
2020-01-13 | 3H-Imidazo[4,5-b]pyridine, 5,7-dichloro-
24485-01-6
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3H-Imidazo[4,5-b]pyridine, 5,7-dichloro-
24485-01-6
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
