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ChemicalBook >> CAS DataBase List >>5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Structure
5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester structure
CAS No.
57800-76-7
Chemical Name:
5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester
Synonyms
Methyl 5-chloro-4-nitrothiophene-2-carboxylate;Ethyl 5-chloro-4-nitrothiophene-2-carboxylate;AKOS 91745;Methyl 5-chloro-4-nitro-2-thiophenecarboxylate;5-Chlor-4-nitro-2-thiophencarbonsaeureMethylester;5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 5-chloro-4-nitro-, methyl ester;5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER, 95+%
CBNumber:
CB7160152
Molecular Formula:
C6H4ClNO4S
Molecular Weight:
221.62
MDL Number:
MFCD08275718
MOL File:
57800-76-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:40
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5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Properties

Melting point 83-84 °C
Boiling point 349.3±37.0 °C(Predicted)
Density 1.576±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
Appearance White to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2934999090

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR480790 Methyl 5-chloro-4-nitro-thiophene-2-carboxylate 97% 57800-76-7 250mg $21 2026-06-04 Buy
Apolloscientific OR480790 Methyl 5-chloro-4-nitro-thiophene-2-carboxylate 97% 57800-76-7 1g $22 2026-06-04 Buy
Apolloscientific OR480790 Methyl 5-chloro-4-nitro-thiophene-2-carboxylate 97% 57800-76-7 5g $78 2026-06-04 Buy
Apolloscientific OR480790 Methyl 5-chloro-4-nitro-thiophene-2-carboxylate 97% 57800-76-7 25g $379 2026-06-04 Buy
Apolloscientific OR480790 Methyl 5-chloro-4-nitro-thiophene-2-carboxylate 97% 57800-76-7 100g $1491 2026-06-04 Buy
Product number Packaging Price Buy
OR480790 250mg $21 Buy
OR480790 1g $22 Buy
OR480790 5g $78 Buy
OR480790 25g $379 Buy
OR480790 100g $1491 Buy

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Chemical Properties, Uses, Production

Synthesis

Methyl-5-chlorothiophene-2-carboxylate

35475-03-7

5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

57800-76-7

Step 2: Preparation of methyl 5-chloro-4-nitrothiophene-2-carboxylate Fuming nitric acid (15 mL) was placed in an ice bath and cooled with saturated brine. Methyl 5-chlorothiophene-2-carboxylate (4.99 g, 28.3 mmol) was added slowly in small batches to avoid violent reaction. After addition, the reaction mixture was stirred in an ice bath for 1 hour. Upon completion of the reaction, the mixture was poured into ice water and a solid was precipitated. The precipitate was collected by filtration, washed with water and dried under vacuum to afford methyl 5-chloro-4-nitrothiophene-2-carboxylate (3.88 g, 58% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 8.17 (1H, s).

References

[1] Patent: EP1688420, 2006, A1. Location in patent: Page/Page column 122
[2] Patent: CN107903208, 2018, A. Location in patent: Paragraph 0136; 0137; 0139
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 2965,2969

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Methanol Methyl-5-chlorothiophene-2-carboxylate 5-Chloro-4-nitrothiophene-2-carboxylic acid

Preparation Products

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Suppliers

Global Suppliers ( 64)
Supplier Tel Email Country ProdList Advantage
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Atop-Pharma (Shanghai) Technology Co., Ltd. +86 (21) 5196-9732 China 996 57
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Nantong MYBio-pharm. Co., Ltd. 0513-85921823 18662920231 sales@ntminyanmedical.com China 4560 58
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
Tetranov Biopharm 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Atop-Pharma (Shanghai) Technology Co., Ltd. 57
Shanghai Topbiochem Technology Co., Ltd 58
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
CEG Chemical Science&Technology Co., Ltd. 58
Bide Pharmatech Ltd. 60
Nantong MYBio-pharm. Co., Ltd. 58
Cool Pharm, Ltd 58

View Latest Price from 5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER pictures 2020-01-15 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
57800-76-7
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester Spectrum

5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER(57800-76-7)1HNMR

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2-Thiophenecarboxylic acid, 4-amino-, hydrochloride

1of4

5-Chlor-4-nitro-2-thiophencarbonsaeureMethylester Ethyl 5-chloro-4-nitrothiophene-2-carboxylate AKOS 91745 Methyl 5-chloro-4-nitro-2-thiophenecarboxylate 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER, 95+% 2-Thiophenecarboxylic acid, 5-chloro-4-nitro-, methyl ester Methyl 5-chloro-4-nitrothiophene-2-carboxylate 5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester 57800-76-7 API intermediates