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ChemicalBook >> CAS DataBase List >>1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Structure
1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid structure
CAS No.
882562-39-2
Chemical Name:
1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
Synonyms
(1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl);(1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic;1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid;[1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridin-3-yl]boronic acid;[1-[(4-Methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]boronic acid;Boronic acid, B-[1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-
CBNumber:
CB71856083
Molecular Formula:
C14H13BN2O4S
Molecular Weight:
316.14
MDL Number:
MFCD10696634
MOL File:
882562-39-2.mol
MSDS File:
SDS
Last updated:2026-05-28 02:33:38
Product description Number Pack Size Price
1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 073173 100.00mg $67
1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 073173 250.00mg $117
1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 073173 1.00g $316
(1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic acid 97% P57593 100mg $92
(1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic acid 97% P57593 250mg $103
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1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Properties

Boiling point 596.1±60.0 °C(Predicted)
Density 1.39±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka 6.82±0.30(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 073173 1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 882562-39-2 100.00mg $67 2026-05-18 Buy
Matrix Scientific 073173 1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 882562-39-2 250.00mg $117 2026-05-18 Buy
Matrix Scientific 073173 1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 882562-39-2 1.00g $316 2026-05-18 Buy
Synthonix P57593 (1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic acid 97% 882562-39-2 100mg $92 2026-05-06 Buy
Synthonix P57593 (1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic acid 97% 882562-39-2 250mg $103 2026-05-06 Buy
Product number Packaging Price Buy
073173 100.00mg $67 Buy
073173 250.00mg $117 Buy
073173 1.00g $316 Buy
P57593 100mg $92 Buy
P57593 250mg $103 Buy

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Chemical Properties,Uses,Production

Synthesis

Triisopropyl borate

5419-55-6

1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]-

226085-18-3

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

882562-39-2

Example 1c: Procedure for the synthesis of 1-toluenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid (8a): 1. Add THF (28.5 kg) and 3-bromo-1-toluenesulfonyl-1H-pyrrolo[2,3-b]pyridine (7a) (4 kg) in a 72 L reaction flask and stir until the solid is completely dissolved. 2. triisopropyl borate (3.2 kg) was added and the reaction mixture was cooled to below -80 °C. The reaction mixture was then cooled to below -80 °C. 3. n-BuLi (4.65 kg) was added dropwise at a rate of 0.6-0.9 kg/hr at -80 to -90 °C. The reaction mixture was cooled to below -80 °C and the temperature was maintained at -80 °C. 4. After addition, maintain the temperature at -80 to -90 °C and monitor the progress of the reaction by HPLC (Method A). Samples were taken and analyzed after 30 min, and the reaction was judged to be complete when the peak area of 3-bromo-1-toluenesulfonyl-1H-pyrrolo[2,3-b]pyridine (7a) was less than 4%. 5. Quench the reaction by slowly adding water (2 kg) to bring the temperature of the mixture back up to 15-25 °C. 6. Transfer the mixture to a 50 L reactor and concentrate below 40 °C at a pressure below -0.08 MPa until no THF is distilled. 7. The residue was dissolved in water (25 kg) and 10% NaOH aqueous solution (26 kg) with stirring until the solids were completely dissolved. 8. The mixture was filtered through a vacuum filter and the filtrate was extracted twice with MTBE (21 kg each) at 20-30°C, stirring for 15 minutes in each extraction and then allowed to stand for 15 minutes. 9. The aqueous phase was adjusted to pH 3-4 with 28L of HCl, keeping the temperature at 10-20°C. The mixture was then extracted with MTBE (21kg each) twice at 20-30°C. 10. The mixture was stirred at 10-15°C for 1 hour and subsequently transferred to a centrifuge for filtration. 11. The filter cake was washed sequentially with water (5 kg) and petroleum ether (5 kg). 12. The filter cake was dried at 35-45°C until the LOD (loss on drying) was less than 3% to give 2.5 kg of an off-white solid (HPLC purity 98.8%, Method A) in 69.4% yield.

References

[1] Patent: WO2013/6634, 2013, A2. Location in patent: Paragraph 0387-0389
[2] Patent: WO2013/70606, 2013, A1. Location in patent: Paragraph 00390-00392
[3] Patent: WO2014/74471, 2014, A1. Location in patent: Paragraph 0275-0277

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Preparation Products And Raw materials

Raw materials

Triisopropyl borate 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-1-[(4-Methylphenyl)sulfonyl]- Tetrahydrofuran n-Butyllithium

Preparation Products

1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21135 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9037 58
CR Corporation Limited 		fred.wen@crcorporation.cn China 8642 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 5927 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53799 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Baoji Guokang Healthchem Co., Ltd. 		58
CR Corporation Limited 		58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		58
Aladdin Scientific 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
Amadis Chemical Company Limited 		58

View Lastest Price from 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid pictures 2021-07-13 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
882562-39-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid pictures 2021-07-10 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
882562-39-2
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid pictures 2019-12-23 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
882562-39-2
 $1.00 1KG 99% 100KG Career Henan Chemical Co

882562-39-2(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid)Related Search:

1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]- 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- [1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]boronic acid 1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid
B-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

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[1-[(4-Methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]boronic acid 1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid Boronic acid, B-[1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]- [1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridin-3-yl]boronic acid (1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl) (1-Tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)boronic 882562-39-2 C14H13BN2O4S CHIRAL CHEMICALS