1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
![1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Structure](CAS2/GIF/1000340-39-5.gif)
- CAS No.
- 1000340-39-5
- Chemical Name:
- 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
- Synonyms
- 4-Chloro-3-bromo-7-azaindole;3-BROMO-4-CHLORO-7-AZAINDOLE;3-Bromo-4-chloro-7-azadindole;3-BROMO-4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-;3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine;3-Bromo-4-chloro-7-azaindole/3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine
- CBNumber:
- CB71871781
- Molecular Formula:
- C7H4BrClN2
- Molecular Weight:
- 231.48
- MDL Number:
- MFCD09880132
- MOL File:
- 1000340-39-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine Aldrich | SYX00215 | 1g | $550 |
| 3-Bromo-4-chloro-1h-pyrrolo[2,3-b]pyridine | B690838 | 100mg | $45 |
| 3-Bromo-4-chloro-7-azaindole | 3H32-D-82 | 1g | $75 |
| 3-Bromo-4-chloro-7-azaindole | 3H32-D-82 | 250mg | $25 |
| 3-Bromo-4-chloro-7-azaindole | X8457 | 5g | $157 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00215 | 3-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine Aldrich | 1000340-39-5 | 1g | $550 | 2025-07-31 | Buy |
| TRC | B690838 | 3-Bromo-4-chloro-1h-pyrrolo[2,3-b]pyridine | 1000340-39-5 | 100mg | $45 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-D-82 | 3-Bromo-4-chloro-7-azaindole | 1000340-39-5 | 1g | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-D-82 | 3-Bromo-4-chloro-7-azaindole | 1000340-39-5 | 250mg | $25 | 2021-12-16 | Buy |
| AK Scientific | X8457 | 3-Bromo-4-chloro-7-azaindole | 1000340-39-5 | 5g | $157 | 2021-12-16 | Buy |
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Chemical Properties,Uses,Production
Synthesis
55052-28-3
![1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-](/CAS2/GIF/1000340-39-5.gif)
1000340-39-5
General procedure for the synthesis of 3-bromo-4-chloro-7-azaindole from 4-chloro-7-azaindole: 1H-4-chloro-pyrrolo[2,3-b]pyridine (0.763 g, 5.0 mmol, 1.0 eq.) was dissolved in N,N-dimethylformamide (DMF, 7.5 mL, 1.5 mL/mmol of substrate), followed by addition of N-bromosuccinimide (NBS, 0.701 g, 5.25 mmol, 1.05 equiv). The reaction mixture was stirred overnight at room temperature protected from light. Upon completion of the reaction, ice water (25 mL, 5 mL/mmol substrate) was added to the mixture to quench the reaction and the precipitate precipitated was collected by filtration. The solid was washed four times with ice water (4 × 10 mL, 2 mL/mmol substrate) to remove residual DMF and by-products. The resulting solid was dried under high vacuum to afford 3-bromo-4-chloro-7-azaindole (0.861 g, 4.6 mmol) as an off-white solid in 92% yield. The melting point of the product was 236 °C (decomposition).1H NMR (300 MHz, DMSO-d6) δ: 7.21 (d, J = 4.2 Hz, 1H, H-5), 7.77 (s, 1H, H-2), 8.20 (d, J = 4.2 Hz, 1H, H-6), 12.35 (br.s, 1H, NH).13C NMR (75 MHz. DMSO-d6) δ: 101.1 (C-3), 113.7 (C-3a), 117.1 (C-5), 125.1 (C-2), 133.8 (C-4), 144.4 (C-6), 147.6 (C-7a). High-resolution mass spectrometry (HRMS, ESI): calculated value C7H5BrClN2 ([M + H]+) is 230.9319, measured value is 230.9319.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 248 - 267
[2] Patent: WO2008/5457, 2008, A2. Location in patent: Page/Page column 180
[3] Patent: WO2008/12635, 2008, A2. Location in patent: Page/Page column 90
1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13456 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro- manufacturers
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2019-07-06 | 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
1000340-39-5
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-4-chloro-
1000340-39-5
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
