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MK 0524

MK 0524 Structure
MK 0524 structure
CAS No.
571170-77-9
Chemical Name:
MK 0524
Synonyms
Laropiprant;CS-623;MK 0524;Cardaptive;Laropiprant, >=99%;Laropiprant(MK0524);MK-0524(Laropiprant)/;MK0524;LAROPIPRANT;MK-0524;Laropiprant, 10 mM in DMSO;[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
CBNumber:
CB71872243
Molecular Formula:
C21H19ClFNO4S
Molecular Weight:
435.9
MDL Number:
MFCD11042421
MOL File:
571170-77-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
MK-0524 ≥98% (HPLC) SML3572 5 mg $109
MK-0524 ≥98% (HPLC) SML3572 25 mg $439
MK-0524 ≥98% 10009835 1mg $63
MK-0524 ≥98% 10009835 5mg $153
MK-0524 ≥98% 10009835 10mg $274
More product size
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MK 0524 Properties

Melting point 175∶C
Boiling point 710.0±60.0 °C(Predicted)
Density 1.48
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);11.47(Max Conc. mM)
form Powder
pka 4.54±0.10(Predicted)
color White to off-white
InChIKey NXFFJDQHYLNEJK-CYBMUJFWSA-N
SMILES OC(C[C@@H](CC1)C2=C1C3=CC(F)=CC(S(C)(=O)=O)=C3N2CC4=CC=C(C=C4)Cl)=O
FDA UNII G7N11T8O78
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

MK 0524 price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3572 MK-0524 ≥98% (HPLC) 571170-77-9 5 mg $109 2026-04-30 Buy
Sigma-Aldrich SML3572 MK-0524 ≥98% (HPLC) 571170-77-9 25 mg $439 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 1mg $63 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 5mg $153 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 10mg $274 2026-04-30 Buy
Product number Packaging Price Buy
SML3572 5 mg $109 Buy
SML3572 25 mg $439 Buy
10009835 1mg $63 Buy
10009835 5mg $153 Buy
10009835 10mg $274 Buy

MK 0524 Chemical Properties,Uses,Production

Uses

Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively[1][2][3].

Definition

ChEBI: Laropiprant is an indolyl carboxylic acid.

Biological Activity

MK-0524 is a potent and selective prostaglandin D2 (PGD2) receptor PTGDR (DP1) antagonist with inverse agonist activity (Ki = 570 pM/DP1, 2.95 nM/TP, 745 nM/DP2, >890 nM for EP1/2/3/4, FP and IP). MK-0524 inhibits cAMP accumulation in PGD2-challenged human platelets (IC50 = 90 pM) and blocks PGD2-induced nasal congestion in a sheep allergic rhinitis model in vivo (by 99% at 0.1 mg/kg i.v.). MK-0524 decreases DP1-dependent basal cAMP level in HEK293 (1-100 nM) without affecting DP1-dependent basal ERK1/2 phosphorylation (up to 1 μM).

in vivo

Laropiprant (0-100 mg/kg; p.o. and i.v.; male Sprague-Dawley rats) exhibits good pharmacokinetic profiles[3].

Pharmacokinetic Analysis in Male Sprague-Dawley rats[3]

RouteDose (mg/kg)AUC0-∞ (μM·hr)Clp (mL/min/kg)Vdss (L/kg)T1/2 (hr)
PO122.71.90.77.4
PO596.02.10.97.6
RouteDose (mg/kg)AUC0-∞ (μM·hr)Cmax (μM)Tmax (hr)F(%)
IV552.615.61.2/

IC 50

DP: 0.57 nM (Ki); TP Receptor: 2.95 nM (Ki)

storage

Store at -20°C

References

[1] Labrecque P, et, al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8(6):e65767.
[2] Sturino CF, et, al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem. 2007 Feb 22;50(4):794-806. DOI:10.1021/jm0603668
[3] Chang SW, et, al. The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys. Xenobiotica. 2007 May;37(5):514-33. DOI:10.1080/00498250601175565

MK 0524 Preparation Products And Raw materials

Raw materials

Preparation Products

MK 0524 Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19853 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49923 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Supplier Advantage
Biochempartner 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
BOC Sciences 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
InvivoChem 		58
GIHI CHEMICALS CO.,LIMITED 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58

View Lastest Price from MK 0524 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Laropiprant pictures 2026-06-02 Laropiprant
571170-77-9
 $32.00-115.00 99.97% 10g TargetMol Chemicals Inc.
Laropiprant pictures 2020-01-13 Laropiprant
571170-77-9
 $1.00 1g 99% 1ton Career Henan Chemical Co
  • Laropiprant pictures
  • Laropiprant
    571170-77-9
  • $32.00-115.00
  • 99.97%
  • TargetMol Chemicals Inc.
  • Laropiprant pictures
  • Laropiprant
    571170-77-9
  • $1.00
  • 99%
  • Career Henan Chemical Co

MK 0524 Spectrum

MK 0524(571170-77-9)1HNMR

571170-77-9(MK 0524)Related Search:

CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO- MK 0524
Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-Laropiprant MK 0524 MK-0524(Laropiprant)/ Laropiprant(MK0524) (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (R)-2-(4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Cardaptive (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid Laropiprant MK 0524 Laropiprant, >=99% MK0524;LAROPIPRANT;MK-0524 CS-623 Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)- Laropiprant, 10 mM in DMSO Laropiprant 571170-77-9 C21H19ClFNO4S