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MK 0524

MK 0524 Structure
MK 0524 structure
CAS No.
571170-77-9
Chemical Name:
MK 0524
Synonyms
Laropiprant;CS-623;MK 0524;Cardaptive;Laropiprant, >=99%;Laropiprant(MK0524);MK-0524(Laropiprant)/;MK0524;LAROPIPRANT;MK-0524;Laropiprant, 10 mM in DMSO;[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid
CBNumber:
CB71872243
Molecular Formula:
C21H19ClFNO4S
Molecular Weight:
435.9
MDL Number:
MFCD11042421
MOL File:
571170-77-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
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MK 0524 Properties

Melting point 175∶C
Boiling point 710.0±60.0 °C(Predicted)
Density 1.48
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);45.88(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.45(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);11.47(Max Conc. mM)
form Powder
pka 4.54±0.10(Predicted)
color White to off-white
InChIKey NXFFJDQHYLNEJK-CYBMUJFWSA-N
SMILES OC(C[C@@H](CC1)C2=C1C3=CC(F)=CC(S(C)(=O)=O)=C3N2CC4=CC=C(C=C4)Cl)=O
FDA UNII G7N11T8O78
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

MK 0524 price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3572 MK-0524 ≥98% (HPLC) 571170-77-9 5 mg $109 2026-04-30 Buy
Sigma-Aldrich SML3572 MK-0524 ≥98% (HPLC) 571170-77-9 25 mg $439 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 1mg $63 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 5mg $153 2026-04-30 Buy
Cayman Chemical 10009835 MK-0524 ≥98% 571170-77-9 10mg $274 2026-04-30 Buy
Product number Packaging Price Buy
SML3572 5 mg $109 Buy
SML3572 25 mg $439 Buy
10009835 1mg $63 Buy
10009835 5mg $153 Buy
10009835 10mg $274 Buy

MK 0524 Chemical Properties, Uses, Production

Uses

Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively[1][2][3].

Definition

ChEBI: Laropiprant is an indolyl carboxylic acid.

Biological Activity

MK-0524 is a potent and selective prostaglandin D2 (PGD2) receptor PTGDR (DP1) antagonist with inverse agonist activity (Ki = 570 pM/DP1, 2.95 nM/TP, 745 nM/DP2, >890 nM for EP1/2/3/4, FP and IP). MK-0524 inhibits cAMP accumulation in PGD2-challenged human platelets (IC50 = 90 pM) and blocks PGD2-induced nasal congestion in a sheep allergic rhinitis model in vivo (by 99% at 0.1 mg/kg i.v.). MK-0524 decreases DP1-dependent basal cAMP level in HEK293 (1-100 nM) without affecting DP1-dependent basal ERK1/2 phosphorylation (up to 1 μM).

in vivo

Laropiprant (0-100 mg/kg; p.o. and i.v.; male Sprague-Dawley rats) exhibits good pharmacokinetic profiles[3].

Pharmacokinetic Analysis in Male Sprague-Dawley rats[3]

RouteDose (mg/kg)AUC0-∞ (μM·hr)Clp (mL/min/kg)Vdss (L/kg)T1/2 (hr)
PO122.71.90.77.4
PO596.02.10.97.6
RouteDose (mg/kg)AUC0-∞ (μM·hr)Cmax (μM)Tmax (hr)F(%)
IV552.615.61.2/

IC 50

DP: 0.57 nM (Ki); TP Receptor: 2.95 nM (Ki)

storage

Store at -20°C

References

[1] Labrecque P, et, al. Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. PLoS One. 2013 Jun 10;8(6):e65767.
[2] Sturino CF, et, al. Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524). J Med Chem. 2007 Feb 22;50(4):794-806. DOI:10.1021/jm0603668
[3] Chang SW, et, al. The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys. Xenobiotica. 2007 May;37(5):514-33. DOI:10.1080/00498250601175565

MK 0524 Preparation Products And Raw materials

Raw materials

Preparation Products

MK 0524 Suppliers

Global Suppliers ( 124)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chemvon Biotechnology Co., Ltd 021-50790412 info@chemvon.com China 371 57
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chemvon Biotechnology Co., Ltd 57
Chembest Research Laboratories Limited 61
LGM Pharma 70
China DongFan Chemical Co.,LTD 66
Beijing HuaMeiHuLiBiological Chemical 58
NCE Biomedical Co.,Ltd. 55
Shanghai T&W Pharmaceutical Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65

View Latest Price from MK 0524 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Laropiprant pictures 2026-06-02 Laropiprant
571170-77-9
 $32.00-115.00 99.97% 10g TargetMol Chemicals Inc.
Laropiprant pictures 2020-01-13 Laropiprant
571170-77-9
 $1.00 1g 99% 1ton Career Henan Chemical Co
  • Laropiprant pictures
  • Laropiprant
    571170-77-9
  • $32.00-115.00
  • 99.97%
  • TargetMol Chemicals Inc.
  • Laropiprant pictures
  • Laropiprant
    571170-77-9
  • $1.00
  • 99%
  • Career Henan Chemical Co

MK 0524 Spectrum

MK 0524(571170-77-9)1HNMR

571170-77-9 (MK 0524) Related Search:

Cyclopent[b]indole, 7-fluoro-1,2,3,4-tetrahydro- MK 0524 Cyclopent[b]indole-3-acetic acid, 5-(aminosulfonyl)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-, (3R)- methyl 2-[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetate (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid
4-[(4-chlorophenyl)Methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(Methylsulfonyl)-Cyclopent[b]indole-3-acetic acid

1of2

Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-Laropiprant MK 0524 MK-0524(Laropiprant)/ Laropiprant(MK0524) (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (R)-2-(4-(4-chlorobenzyl)-7-fluoro-5-(Methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid Cardaptive (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid Laropiprant MK 0524 Laropiprant, >=99% MK0524;LAROPIPRANT;MK-0524 CS-623 Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)- Laropiprant, 10 mM in DMSO Laropiprant 571170-77-9 C21H19ClFNO4S