3-(2-Chloroacetyl)pyridine hydrochloride
- CAS No.
- 61889-48-3
- Chemical Name:
- 3-(2-Chloroacetyl)pyridine hydrochloride
- Synonyms
- Nsc77639;3-(2-Chloroacetyl)pyridine HCl;Chloroacetylpyridine Hydrochloride;2-CHLORO-1-(PYRIDIN-3-YL)ETHANONE HCL;3-(2-Chloroacetyl)pyridine hydrochloride;Ketone, chloromethyl-3-pyridyl, hydrochloride;2-chloro-1-(3-pyridinyl)ethanone hydrochloride;2-chloro-1-(pyridin-3-yl)ethan-1-one hydrochloride;Ethanone, 2-chloro-1-(3-pyridinyl)-, hydrochloride (1:1)
- CBNumber:
- CB71876377
- Molecular Formula:
- C7H7Cl2NO
- Molecular Weight:
- 0
- MDL Number:
- MFCD09033889
- MOL File:
- 61889-48-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride | LCA88948 | 2.5g | $324.5 |
| 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | OR931181 | 100mg | $29 |
| 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | OR931181 | 250mg | $39 |
| 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | OR931181 | 5g | $258 |
| 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | AS114472 | 1g | $116 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H315-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933399990 |
3-(2-Chloroacetyl)pyridine hydrochloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | LCA88948 | 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride | 61889-48-3 | 2.5g | $324.5 | 2026-06-04 | Buy |
| Apolloscientific | OR931181 | 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | 61889-48-3 | 100mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR931181 | 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | 61889-48-3 | 250mg | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR931181 | 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | 61889-48-3 | 5g | $258 | 2026-06-04 | Buy |
| Activate Scientific | AS114472 | 2-Chloro-1-(pyridin-3-yl)ethanone hydrochloride 95% | 61889-48-3 | 1g | $116 | 2026-06-04 | Buy |
3-(2-Chloroacetyl)pyridine hydrochloride Chemical Properties,Uses,Production
Uses
3-(2-Chloroacetyl)pyridine Hydrochloride is used in the synthetic preparation of chiral amino(pyridinyl)ethanol via lipase-mediated kinetic resolution.
Synthesis
350-03-8
61889-48-3
Example 5 Synthesis of 3-(2-chloroacetyl)pyridine hydrochloride: 3-Acetylpyridine (100 g, 0.83 mol) was dissolved in ether (1 L) under rapid stirring conditions, and an ether solution of 1N hydrogen chloride (950 mL) was slowly added. The solid produced by the reaction was filtered, washed with ether and dried to give the hydrochloride intermediate (129 g, 0.83 mol). This hydrochloride intermediate was transferred to a 5L reactor fitted with a mechanical stirrer, dissolved with a solution of acetic acid in 1N HCl (830 mL) and stirred until the solution was clarified. Subsequently, N-chlorosuccinimide (111 g, 0.83 mol) was added and the reaction mixture was yellow in color. The reaction solution was stirred at room temperature for 18 h. The reaction solution gradually transformed into a colorless suspension. The solid product was collected by filtration and washed with ether. The filtrate was further treated with N-chlorosuccinimide (80 g, 0.6 mol) overnight to recover additional product. The final white solid product 3-(2-chloroacetyl)pyridine hydrochloride (152 g, 95% yield) was obtained. The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6) and mass spectrometry (EI): 1H-NMR δ 10.3 (br s, 1H), 9.27 (s, 1H), 8.96 (d, 1H, J = 5.1 Hz), 8.62 (d, 1H, J = 9.9 Hz), 7.89 (m, 1H), 5.30 (s, 2H); MS (EI) m/z 155 (M+).
References
[1] Patent: WO2005/113505, 2005, A1. Location in patent: Page/Page column 17
[2] Patent: US6469031, 2002, B1
[3] Patent: EP1040106, 2002, B1
[4] Patent: WO2005/113505, 2005, A1. Location in patent: Page/Page column 13
[5] Organic Process Research and Development, 2003, vol. 7, # 3, p. 285 - 288
3-(2-Chloroacetyl)pyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-Chloroacetyl)pyridine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8491 | 58 |
| Xiamen Shindano Biotechnology Co.,ltd | 0592-6266840 15750707980 | sales@chemsdano.com | China | 291 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| VladaChem GmbH | +49-7246-3082843 +86-18411632868 | info@vladachem.de | Germany | 1854 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +86-15195660023 | 3899766280@qq.com | China | 26349 | 58 |
View Lastest Price from 3-(2-Chloroacetyl)pyridine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 3-(2-Chloroacetyl)pyridine hydrochloride
61889-48-3
|
$1.00 | 1KG | 98%-99.9% | 200kg | Career Henan Chemical Co |
-
- 3-(2-Chloroacetyl)pyridine hydrochloride
61889-48-3
- $1.00
- 98%-99.9%
- Career Henan Chemical Co
