Troxipide
- CAS No.
- 30751-05-4
- Chemical Name:
- Troxipide
- Synonyms
- KU 54;Aplace;TROXIPIDE;Troxipide RS;Troxipide API;Troxipide Troxipide;Troxipide - Bio-X ?;TROXIPIDE 98.5% MIN;Triheptanoin Impurity 10;Troxipide, 10 mM in DMSO
- CBNumber:
- CB7188765
- Molecular Formula:
- C15H22N2O4
- Molecular Weight:
- 294.35
- MDL Number:
- MFCD00866876
- MOL File:
- 30751-05-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 177.0 to 181.0 °C |
|---|---|
| Boiling point | 407.5±45.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.66±0.20(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 30751-05-4(CAS DataBase Reference) |
| FDA UNII | W6QJX1Q00Z |
| ATC code | A02BX11 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| RTECS | CV5792600 | |||||||||
| HS Code | 2933.39.9200 | |||||||||
| NFPA 704 |
|
Troxipide price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T2909 | Troxipide >98.0%(HPLC)(T) | 30751-05-4 | 1g | $267 | 2026-04-30 | Buy |
| TCI Chemical | T2909 | Troxipide >98.0%(HPLC)(T) | 30751-05-4 | 5g | $106 | 2022-04-27 | Buy |
| Cayman Chemical | 30616 | Troxipide ≥98% | 30751-05-4 | 500mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 30616 | Troxipide ≥98% | 30751-05-4 | 1g | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 30616 | Troxipide ≥98% | 30751-05-4 | 5g | $516 | 2026-04-30 | Buy |
Troxipide Chemical Properties, Uses, Production
Synthesis
The product was prepared by condensation of 3,4,5-trimethoxybenzoic acid or its ester with 3-aminopyridine, followed by medium-pressure catalytic hydrogenation. The synthetic route is shown in Figure 1.
Figure 1 shows the synthetic route of troxipide.
The operation steps are as follows: 8.5 g (0.04 mol) of 3,4,5-trimethoxybenzoic acid, 50 ml of chloroform, and 10.5 g (0.133 mol) of pyridine are added to a 250 ml three-necked flask equipped with a mechanical stirrer, reflux condenser, and addition funnel. The mixture is heated to 30-40°C, stirred, and 3.4 g (0.022 mol) of phosphorus oxychloride is added dropwise over 10 min. The temperature is increased, and the mixture is reacted at 60-70°C for 1 h before being cooled to 50°C. At this temperature, a solution consisting of 3.8 g (0.04 mol) of 3-aminopyridine and 20 mL of chloroform was added dropwise over approximately 20 minutes. The solution was then refluxed for 40 minutes, followed by the addition of 40 mL of water at 50°C. The chloroform, water, and pyridine were distilled off under reduced pressure. The resulting solid was stirred with 150 mL of water to form a turbid solution, neutralized to pH 8 with NaHCO3, cooled, crystallized, and filtered to obtain the product 3,4,5-trimethoxy-N-3-pyridylbenzamide. 3.0 g (approximately 0.01 mol) of 3,4,5-trimethoxy-N-3-pyridylbenzamide, 30 mL of ethanol, 9 mL of water, 1.2 mL of concentrated hydrochloric acid, and 1.0 g of 5% Pd-C were placed in an autoclave and hydrogenated at 60-70°C and a maximum pressure of 5 MPa for 2 seconds. h, until no hydrogen is absorbed, cool, filter out the catalyst, evaporate ethanol under reduced pressure to obtain a colorless to pale yellow solid, neutralize the crude product with dilute NaHCO3 to pH 8-9, collect the precipitate, filter, and obtain the product.
Description
Troxipide is an antiulcer agent which is suggested to actvia beneficial effects on gastric glycoprotein metabolism and blood flow.
Originator
Kyorin (Japan)
Uses
Troxipide is a drug used in the treatment of gastroesophageal reflux disease. It is capable of inhibiting the chemotactic migration and superoxide generation in the gastric mucosa.
Definition
ChEBI: Troxipide is a member of benzamides.
brand name
APLACE
Troxipide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6744 | 52 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| TIPR Pharmaceutical Responsible Co., Ltd. | 022-23009155 23006946 | api@cnpha.com | China | 28 | 68 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2696 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
View Latest Price from Troxipide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Troxipide
30751-05-4
|
1KG | 99% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-04-21 | Troxipide
30751-05-4
|
$54.00 | 99.56% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Troxipide
30751-05-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
