9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid
- CAS No.
- 36614-31-0
- Chemical Name:
- 9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid
- Synonyms
- PROSTAGLANDIN A3;PGA3;KSIRMUMXJFWKAC-FHJHOUOTSA-N;Recombinant Human Pepsin A-3/PGI/PGA3 Protein, His Tag;9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid;(5Z,13E,15S,17Z)-15-Hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid;Prosta-5,10,13,17-tetraen-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S,17Z)-;7-[(1R,2S)-2-[(3S)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid
- CBNumber:
- CB7189005
- Molecular Formula:
- C20H28O4
- Molecular Weight:
- 332.43
- MDL Number:
- MFCD00065729
- MOL File:
- 36614-31-0.mol
- MSDS File:
- SDS
| Boiling point | 526.401±50.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.120±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | -20°C |
| solubility | DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1) |
| pka | 4.751±0.10(predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10310 | Prostaglandin A3 ≥98% | 36614-31-0 | 25μg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 10310 | Prostaglandin A3 ≥98% | 36614-31-0 | 50μg | $176 | 2026-04-30 | Buy |
| Cayman Chemical | 10310 | Prostaglandin A3 ≥98% | 36614-31-0 | 100μg | $322 | 2026-04-30 | Buy |
| ChemScene | CS-0064394 | Prostaglandin A3 | 36614-31-0 | 25μg | $231 | 2026-06-04 | Buy |
| ChemScene | CS-0064394 | Prostaglandin A3 | 36614-31-0 | 50μg | $381 | 2026-06-04 | Buy |
9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid Chemical Properties, Uses, Production
Description
Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-
Uses
Prostaglandin A3 is a non-enzymatic dehydration product of prostaglandin E3 (PGE3). Prostaglandin A3 showed good affinity for canine EP2 and EP4 receptors with IC50 values of 120 and 20 nM, respectively. The Ki value of Prostaglandin A3 for human PPARγ was 188 μM[1][2][3].
Definition
ChEBI: Prostaglandin A3 is a member of the class of prostaglandins A that is prosta-5,10,13,17-tetraen-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 5Z,13E,15S,17Z-stereoisomer). It has a role as a mammalian metabolite. It is a prostaglandins A and a secondary allylic alcohol. It is a conjugate acid of a prostaglandin A3(1-).
IC 50
EP2: 120 nM (IC50); EP4: 20 nM (IC50); PPAR-γ: 188 μM (Ki)
References
[1] Hibbs TA, et al. Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins Other Lipid Mediat. 1999 May;57(2-3):133-47. DOI:10.1016/s0090-6980(98)00081-1
[2] Castleberry TA, et al. Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins Other Lipid Mediat. 2001 Jul;65(4):167-87. DOI:10.1016/s0090-6980(01)00129-0
[3] Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417(1-2):77-89. DOI:10.1016/s0014-2999(01)00907-4
9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid Preparation Products And Raw materials
Raw materials
Preparation Products
9-Oxo-15s-hydroxy-prosta-5z,10,13e,17z-tetraen-1-oic acid Suppliers
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