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1-Boc-4-bromopyrazole

1-Boc-4-bromopyrazole structure

CAS No.: 1150271-23-0

Chemical Name:: 1-Boc-4-bromopyrazole

Synonyms: 1-Boc-4-bromopyrazole;N-Boc-4-broMopyrazole;1-Boc-4-bromopyrazole;tert-butyl 4-bromopyrazole-1-carboxylate;t-Butyl 4-bromo-1H-pyrazole-1-carboxylate;tert-Butyl 4-bromo-1H-pyrazol-1-carboxylate;1H-Pyrazole-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester

CBNumber:: CB72101292

Molecular Formula:: C8H11BrN2O2

Molecular Weight:: 247.09

MDL Number:: MFCD09999163

MOL File:: 1150271-23-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:24:16

Product description	Number	Pack Size	Price
1-Boc-4-bromopyrazole 97%	694266	1g	$127
1-Boc-4-bromopyrazole 97%	694266	10g	$603
4-Bromo-1H-pyrazole, N1-BOC protected >97%	OR42171	5g	$21
4-Bromo-1H-pyrazole, N1-BOC protected >97%	OR42171	25g	$32
4-Bromo-1H-pyrazole, N1-BOC protected >97%	OR42171	100g	$122

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1-Boc-4-bromopyrazole Properties

Melting point	48-52 °C
Boiling point	288.7±32.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	solid
pka	-3.17±0.12(Predicted)
Appearance	Off-white to light yellow Solid
InChI	InChI=1S/C8H11BrN2O2/c1-8(2,3)13-7(12)11-5-6(9)4-10-11/h4-5H,1-3H3
InChIKey	IQEFCRDQVLIADR-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)C=C(Br)C=N1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P501
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
HS Code	2933199090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

1-Boc-4-bromopyrazole price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	694266	1-Boc-4-bromopyrazole 97%	1150271-23-0	1g	$127	2023-06-20	Buy
Sigma-Aldrich	694266	1-Boc-4-bromopyrazole 97%	1150271-23-0	10g	$603	2023-06-20	Buy
Apolloscientific	OR42171	4-Bromo-1H-pyrazole, N1-BOC protected >97%	1150271-23-0	5g	$21	2026-06-04	Buy
Apolloscientific	OR42171	4-Bromo-1H-pyrazole, N1-BOC protected >97%	1150271-23-0	25g	$32	2026-06-04	Buy
Apolloscientific	OR42171	4-Bromo-1H-pyrazole, N1-BOC protected >97%	1150271-23-0	100g	$122	2026-06-04	Buy

Product number	Packaging	Price	Buy
694266	1g	$127	Buy
694266	10g	$603	Buy
OR42171	5g	$21	Buy
OR42171	25g	$32	Buy
OR42171	100g	$122	Buy

1-Boc-4-bromopyrazole Chemical Properties,Uses,Production

Synthesis

2075-45-8

24424-99-5

1150271-23-0

Step 1: Preparation of tert-butyl 4-bromo-1H-pyrazole-1-carboxylate Di-tert-butyl dicarbonate (Boc2O, 2.34 mL, 10.2 mmol) was slowly added to a solution of 4-bromo-1H-pyrazole (1 g, 6.8 mmol) in acetonitrile (20 mL) at 0 °C. Subsequently, triethylamine (3.3 mL, 23.8 mmol) and 4-dimethylaminopyridine (DMAP, 0.166 g, 1.36 mmol) were added sequentially to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted with ethyl acetate (100 mL × 3). The organic phases were combined, washed sequentially with water (100 mL) and saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford tert-butyl 4-bromo-1H-pyrazole-1-carboxylate (1.65 g, 98% yield) as a colorless liquid. 1H NMR (400 MHz, CDCl3) δ 8.09 (s, 1H), 7.66 (s, 1H), 1.65 (s, 9H).

References

[1] Patent: WO2016/49165, 2016, A1. Location in patent: Paragraph 00161
[2] Patent: WO2018/172250, 2018, A1. Location in patent: Page/Page column 300
[3] Patent: CN106188116, 2016, A. Location in patent: Paragraph 0016
[4] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 142
[5] Arkivoc, 2014, vol. 2014, # 6, p. 54 - 71

1-Boc-4-bromopyrazole Preparation Products And Raw materials

Raw materials

4-Bromopyrazole Di-tert-butyl dicarbonate Acetonitrile 4-Dimethylaminopyridine Triethylamine

Preparation Products

1-Boc-pyrazole-4-boronic acid pinacol ester

1-Boc-4-bromopyrazole Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	912	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9035	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
Suzhou ARTK Medchem Co., Ltd.	+86-18168183658	sales1@artkmedchem.com	China	39007	58
Nanjing Moldeep Biochemical Co., Ltd.	+86-25-58282389 +86-17351037455	inquiries@moldeep.com	China	19999	58

Supplier	Advantage
career henan chemical co	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Baoji Guokang Healthchem Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58
Nanjing Moldeep Biochemical Co., Ltd.	58

View Lastest Price from 1-Boc-4-bromopyrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	1-Boc-4-bromopyrazole 1150271-23-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	1-Boc-4-bromopyrazole 1150271-23-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2020-01-03	1-Boc-4-bromopyrazole 1150271-23-0	$1.00	1KG	99%	200kg	Career Henan Chemical Co

1-Boc-4-bromopyrazole
1150271-23-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-Boc-4-bromopyrazole
1150271-23-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-Boc-4-bromopyrazole
1150271-23-0
$1.00
99%
Career Henan Chemical Co

1-Boc-4-bromopyrazole Spectrum

1-Boc-4-bromopyrazole(1150271-23-0)¹HNMR

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