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8-Chloro-2-methylimidazo[1,2-a]pyrazine

8-Chloro-2-methylimidazo[1,2-a]pyrazine structure

CAS No.: 85333-43-3

Chemical Name:: 8-Chloro-2-methylimidazo[1,2-a]pyrazine

Synonyms: 8-chloro-2-MethyliMidazo[1;8-Chloro-2-methylimidazo[1,2-a]pyrazine;8-Chloro-2-MethyliMidazol[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 8-chloro-2-methyl-

CBNumber:: CB72453753

Molecular Formula:: C7H6ClN3

Molecular Weight:: 167.6

MDL Number:: MFCD09999202

MOL File:: 85333-43-3.mol

Last updated:2026-09-12 18:54:50

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8-Chloro-2-methylimidazo[1,2-a]pyrazine Properties

Density	1.43±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	2.51±0.30(Predicted)
Appearance	Light brown to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405
HS Code	2933998090

8-Chloro-2-methylimidazo[1,2-a]pyrazine price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR903685	8-Chloro-2-methylimidazo[1,2-a]pyrazine 97%	85333-43-3	250mg	$30	2026-06-04	Buy
Apolloscientific	OR903685	8-Chloro-2-methylimidazo[1,2-a]pyrazine 97%	85333-43-3	1g	$81	2026-06-04	Buy
Apolloscientific	OR903685	8-Chloro-2-methylimidazo[1,2-a]pyrazine 97%	85333-43-3	5g	$319	2026-06-04	Buy
Activate Scientific	AS30877	8-Chloro-2-methylimidazo[1,2-a]pyrazine 97%	85333-43-3	1g	$182	2026-06-04	Buy
Activate Scientific	AS30877	8-Chloro-2-methylimidazo[1,2-a]pyrazine 97%	85333-43-3	5g	$536	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR903685	250mg	$30	Buy
OR903685	1g	$81	Buy
OR903685	5g	$319	Buy
AS30877	1g	$182	Buy
AS30877	5g	$536	Buy

8-Chloro-2-methylimidazo[1,2-a]pyrazine Chemical Properties, Uses, Production

Synthesis

6863-73-6

78-95-5

85333-43-3

The reaction was carried out with 2-amino-3-chloropyrazine (48.7 g, 375.8 mmol) and chloroacetone (120 mL, 1504.5 mmol) in a sealed tube with stirring for 16 h at 90 °C under light protection. Upon completion of the reaction, it was cooled to room temperature, ether (Et2O) was added and the solid product formed was collected by filtration. After washing the solid with additional ether, it was suspended in saturated sodium carbonate solution and extracted with dichloromethane (DCM). The organic layer was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum to remove the solvent. The crude product was purified by recrystallization from ether to give Intermediate 4 (43.2 g, 68% yield) as a white solid, which could be used in subsequent reactions without further purification. The melting point of the intermediate was 133.5-138.6 °C (determined by WRS-2A melting point apparatus).

References

[1] Patent: WO2011/110545, 2011, A1. Location in patent: Page/Page column 73-74
[2] Patent: US2012/329792, 2012, A1. Location in patent: Page/Page column 33-34
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4196 - 4212
[4] Patent: US2015/203498, 2015, A1. Location in patent: Paragraph 0167; 0168
[5] Patent: WO2016/185342, 2016, A1. Location in patent: Page/Page column 39

8-Chloro-2-methylimidazo[1,2-a]pyrazine Preparation Products And Raw materials

Raw materials

2-Amino-3-chloropyrazine Chloroacetone 1-Bromo-2,2-dimethoxypropane Sodium carbonate

Preparation Products

8-chloro-3-iodo-2-MethyliMidazo[1,2-a]pyrazine

8-Chloro-2-methylimidazo[1,2-a]pyrazine Suppliers

Global Suppliers ( 71)

Supplier	Tel	Email	Country	ProdList	Advantage
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
China Langchem Inc.	0086-21-58956006		China	7798	57
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai Tombiopharma Chemical Co. Ltd.	13391076197	tombiopharma@163.com	China	4986	55
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Bellen Chemistry Co., Ltd.	010-60400365-8001 15910885229	service@bellenchem.com	China	4514	60
Shanghai Boyners Pharm-Tech Co., Ltd.	13817873692	mkt@boynerspharm.com	China	1707	55
ShangHai Movin Pharmaceutical Co., Ltd.	13681854265	info@moenpharm.com	China	488	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Hangzhou Molcore Biopharmatech Co.,Ltd	400-711-5280 86-571-81025280	sales@molcore.com	China	9957	58

Supplier	Advantage
Pure Chemistry Scientific Inc.	62
China Langchem Inc.	57
Bide Pharmatech Ltd.	60
Shanghai Tombiopharma Chemical Co. Ltd.	55
Cool Pharm, Ltd	58
Bellen Chemistry Co., Ltd.	60
Shanghai Boyners Pharm-Tech Co., Ltd.	55
ShangHai Movin Pharmaceutical Co., Ltd.	55
Amadis Chemical Company Limited	58
Hangzhou Molcore Biopharmatech Co.,Ltd	58

8-Chloro-2-methylimidazo[1,2-a]pyrazine Spectrum

8-CHLORO-2-METHYLIMIDAZO[1,2-A]PYRAZINE(85333-43-3)¹HNMR

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8-chloro-2-MethyliMidazo[1 8-Chloro-2-MethyliMidazol[1,2-a]pyrazine Imidazo[1,2-a]pyrazine, 8-chloro-2-methyl- 8-Chloro-2-methylimidazo[1,2-a]pyrazine 85333-43-3