(1-Methyl-1H-pyrazol-5-yl)-boronic acid
- CAS No.
- 720702-41-0
- Chemical Name:
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
- Synonyms
- (2-methylpyrazol-3-yl)boronic acid;-5-yL;(1-Methyl-1H-pyrazol-5-yl...;1-Methylpyrazole-5-boric acid,;1-Methyl-pyrazole-5-boronic acid;(2-methyl-3-pyrazolyl)boronic acid;1-Methyl-1H-pyrazole-5-boronic acid;1-Methyl-1H-pyrazol-5-yl-5-boronic acid;(1-Methyl-1H-pyrazol-5-yl)-boronic acid;720702-41-0
- CBNumber:
- CB72462274
- Molecular Formula:
- C4H7BN2O2
- Molecular Weight:
- 125.92
- MDL Number:
- MFCD11053031
- MOL File:
- 720702-41-0.mol
- MSDS File:
- SDS
| Boiling point | 323.0±34.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 8.00±0.58(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C4H7BN2O2/c1-7-4(5(8)9)2-3-6-7/h2-3,8-9H,1H3 |
| InChIKey | MGNBKNBEZGLHNF-UHFFFAOYSA-N |
| SMILES | B(C1N(C)N=CC=1)(O)O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Risk Statements | 36 |
| Safety Statements | 26 |
| HS Code | 2933199090 |
(1-Methyl-1H-pyrazol-5-yl)-boronic acid price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2680 | (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride) | 720702-41-0 | 1G | $100 | 2026-04-30 | Buy |
| TCI Chemical | M2680 | (1-Methyl-1H-pyrazol-5-yl)boronic Acid (contains varying amounts of Anhydride) | 720702-41-0 | 5G | $296 | 2026-04-30 | Buy |
| Activate Scientific | AS12315 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid 95% | 720702-41-0 | 5g | $30 | 2026-06-04 | Buy |
| Activate Scientific | AS12315 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid 95% | 720702-41-0 | 25g | $91 | 2026-06-04 | Buy |
| Activate Scientific | AS12315 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid 95% | 720702-41-0 | 100g | $248 | 2026-06-04 | Buy |
(1-Methyl-1H-pyrazol-5-yl)-boronic acid Chemical Properties, Uses, Production
Uses
1-Methyl-1H-pyrazole-5-boronic Acid acts as a reagent for the design, synthesis and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on ‘reversed’ amide scaffold.
Synthesis
930-36-9
720702-41-0
General procedure for the synthesis of 1-methyl-1H-pyrazole-5-boronic acid from 1-methylpyrazole: 1-methylpyrazole (25 mL, 0.3 mol) was dissolved in 500 mL of tetrahydrofuran (THF). The solution was then cooled to -78°C in a dry ice/isopropanol bath. After the solution temperature stabilized at -78 °C, n-butyllithium (n-BuLi, 140 mL, 0.40 mol) was slowly added dropwise through the cannula. After the dropwise addition, the reaction mixture was stirred continuously at -78 °C for 1.5 hours. Next, triisopropyl borate (280 mL, 1.2 mol) was added to the reaction system via cannula and the reaction mixture was allowed to slowly warm from -78 °C to 0 °C while stirring overnight. Upon completion of the reaction, the pH of the mixture was adjusted to 6 with 1 N hydrochloric acid (HCl).Subsequently, THF was evaporated under reduced pressure and the remaining aqueous phase was extracted with ethyl acetate (EtOAc, 2 × 100 mL). Finally, the solid was collected by filtration to afford 108 g (100% yield) of 1-methyl-1H-pyrazole-5-boronic acid as a yellow solid.
References
[1] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 101
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[3] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 6, p. 931 - 939
[4] Patent: WO2004/58722, 2004, A1. Location in patent: Page 63; 62
(1-Methyl-1H-pyrazol-5-yl)-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| New Energy Chemicals | 0515-82159099 13770142076 | info@njuchem.com | China | 251 | 65 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from (1-Methyl-1H-pyrazol-5-yl)-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
|
$500.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (1-Methyl-1H-pyrazol-5-yl)-boronic acid
720702-41-0
- $500.00
- 98%
- Career Henan Chemical Co
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