N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide
![N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide Structure](CAS2/GIF/740873-06-7.gif)
- CAS No.
- 740873-06-7
- Chemical Name:
- N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide
- Synonyms
- Naluzotan;TAK-448;PRX 00023;Unii-lq54E5B4ew;N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide;Acetamide, N-[3-[4-[4-[[(cyclohexylmethyl)sulfonyl]amino]butyl]-1-piperazinyl]phenyl]-
- CBNumber:
- CB72484704
- Molecular Formula:
- C23H38N4O3S
- Molecular Weight:
- 450.64
- MDL Number:
- MFCD09833676
- MOL File:
- 740873-06-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Naluzotan >99.99%(Mayvarybetweenbatches) | orb1706933 | 1mg | $740 |
| Naluzotan >99.99%(Mayvarybetweenbatches) | orb1706933 | 5mg | $1470 |
| N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide >98% | AA00FGGV | 1mg | $980 |
| Naluzotan 98% | AD248503 | 5MG | $1715 |
| PRX-00023 95.00% | API0008107 | 5MG | $502.46 |
| Density | 1.169 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 11.49±0.40(Predicted) |
| color | White to light yellow |
| FDA UNII | LQ54E5B4EW |
N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb1706933 | Naluzotan >99.99%(Mayvarybetweenbatches) | 740873-06-7 | 1mg | $740 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1706933 | Naluzotan >99.99%(Mayvarybetweenbatches) | 740873-06-7 | 5mg | $1470 | 2026-05-06 | Buy |
| aablocks | AA00FGGV | N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide >98% | 740873-06-7 | 1mg | $980 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD248503 | Naluzotan 98% | 740873-06-7 | 5MG | $1715 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | API0008107 | PRX-00023 95.00% | 740873-06-7 | 5MG | $502.46 | 2021-12-16 | Buy |
N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide Chemical Properties,Uses,Production
Uses
Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM.
in vivo
In rats Naluzotan shows 11% oral bioavailability with a serum t1/2 of 23.5 h when administrated po, attaining a Cmax level of 24 ± 13 ng/mL (3 mg/kg, po). Naluzotan shows significant brain penetration, achieving a brain:serum concentration ratio of approximately 0.5 in the rat at 1 h following either intravenous or oral administration and reaching brain concentration approximately equivalent to that of buspirone. In dogs the pharmacokinetic profile of naluzotan shows 16% oral bioavailability, a serum t1/2 of 1.1 h po, and a Cmax level of 174 ± 141 ng/mL (3 mg/kg, po)[1]. PRX-00023 (0.01-0.05 mg/kg, i.p.) significantly reduces USV rates, but done of these doses produce sedation in rats[2].
IC 50
5-HT1A Receptor: 20 nM (IC50); 5-HT1A Receptor: 5.1 nM (Ki); hERG K+ channel: 3800 nM (IC50)
References
[1] Becker OM, et al. An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. J Med Chem. 2006 Jun 1;49(11):3116-35. DOI:10.1021/jm0508641
[2] Brunelli SA, et al. PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety. Pharmacol Biochem Behav. 2009 Nov;94(1):8-15. DOI:10.1016/j.pbb.2009.06.014
N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[3-[4-[4-[(Cyclohexylmethylsulfonyl)amino]butyl]piperazin-1-yl]phenyl]acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3971 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5945 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9112 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7775 | 56 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303; | Caroline@youngshechem.com | China | 4801 | 58 |
