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XL647

XL647 Structure
XL647 structure
CAS No.
781613-23-8
Chemical Name:
XL647
Synonyms
XL-647;Tesevatinib;KD-019;XL647 /EXEL-7647;Tesevatinib(XL647);EXEL-7647;XL-647;XL 647;Tesevatinib, 10 mM in DMSO;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
CBNumber:
CB82628532
Molecular Formula:
C24H25Cl2FN4O2
Molecular Weight:
491.39
MDL Number:
MFCD23726660
MOL File:
781613-23-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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XL647 Properties

Boiling point 567.9±50.0 °C(Predicted)
Density 1.356
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form A solid
pka 10.16±0.40(Predicted)
color White to off-white
InChIKey HVXKQKFEHMGHSL-QKDCVEJENA-N
SMILES N(C1C=CC(Cl)=C(Cl)C=1F)C1=NC=NC2C=C(OC[C@H]3C[C@@]4([H])CN(C)C[C@@]4([H])C3)C(OC)=CC1=2 |&1:19,21,27,r|
FDA UNII F6XM2TN5A1
NCI Drug Dictionary tesevatinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310

XL647 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 1mg $107 2026-04-30 Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 5mg $396 2026-04-30 Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 10mg $740 2026-04-30 Buy
Biosynth FX103992 XL 647 781613-23-8 0.05g $1891.84 2026-06-04 Buy
Biosynth FX103992 XL 647 781613-23-8 0.1g $2926.99 2026-06-04 Buy
Product number Packaging Price Buy
27049 1mg $107 Buy
27049 5mg $396 Buy
27049 10mg $740 Buy
FX103992 0.05g $1891.84 Buy
FX103992 0.1g $2926.99 Buy

XL647 Chemical Properties, Uses, Production

Uses

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

Definition

ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.

in vivo

Tesevatinib (XL-647) shows potent and long-lived inhibition of the WT EGFRin vivo. Tesevatinib (XL-647) substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density[1].

IC 50

EGFR: 0.3 nM (IC50); ErbB2: 16 nM (IC50); KDR: 1.5 nM (IC50); Flt-4: 8.7 nM (IC50)

XL647 Preparation Products And Raw materials

Raw materials

Preparation Products

XL647 Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
Jiangsu yize medical technology co. LTD 18962082606 3394205705@qq.com China 1751 58
Haiji Pharmaceutical Technology (Suzhou) Co., Ltd 18012778619 3394205705@qq.com China 9899 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
shanghai cooperpharm co.,LTD . +86-021-58975553 sales@cooperpharm.com China 1210 56
Wulechem Co., Ltd. 13761914825 wulesian@wulechem.com China 285 58
GIHI CHEMICALS CO.,LTD 0086-571-86217390 Sales@gihichem.com China 858 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
Jiangsu yize medical technology co. LTD 58
Haiji Pharmaceutical Technology (Suzhou) Co., Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
shanghai cooperpharm co.,LTD . 56
Wulechem Co., Ltd. 58
GIHI CHEMICALS CO.,LTD 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Bide Pharmatech Ltd. 60

View Latest Price from XL647 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tesevatinib pictures 2026-07-27 Tesevatinib
781613-23-8
 $109.00-482.00 99.99% 10g TargetMol Chemicals Inc.
XL-647 pictures 2019-08-08 XL-647
781613-23-8
 $3.00 1KG 99% 100kg Career Henan Chemical Co
  • Tesevatinib pictures
  • Tesevatinib
    781613-23-8
  • $109.00-482.00
  • 99.99%
  • TargetMol Chemicals Inc.
  • XL-647 pictures
  • XL-647
    781613-23-8
  • $3.00
  • 99%
  • Career Henan Chemical Co

XL647 Spectrum

XL-647(781613-23-8)1HNMR

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BMS 777607 Fatostatin A Fatostatin A

1of4

Tesevatinib(XL647) N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine EXEL-7647;XL-647;XL 647 KD-019 Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine XL647,Tesevatinib,EXEL 7647,KD019,HER1,Ephrin Receptor,Inhibitor,VEGFR,KD 019,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,EGFR,ErbB-1,XL 647,EXEL7647,inhibit XL647 /EXEL-7647 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]- N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine Tesevatinib, 10 mM in DMSO Tesevatinib XL-647 781613-23-8 C24H25Cl2FN4O2