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XL647

XL647 Structure
XL647 structure
CAS No.
781613-23-8
Chemical Name:
XL647
Synonyms
XL-647;Tesevatinib;KD-019;XL647 /EXEL-7647;Tesevatinib(XL647);EXEL-7647;XL-647;XL 647;Tesevatinib, 10 mM in DMSO;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
CBNumber:
CB82628532
Molecular Formula:
C24H25Cl2FN4O2
Molecular Weight:
491.3853032
MDL Number:
MFCD23726660
MOL File:
781613-23-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:38:02
Product description Number Pack Size Price
XL647 ≥98% 27049 1mg $107
XL647 ≥98% 27049 5mg $396
XL647 ≥98% 27049 10mg $740
XL647 27049 1mg $97
XL647 27049 10mg $672
Request For Quotation

XL647 Properties

Boiling point 567.9±50.0 °C(Predicted)
Density 1.356
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form A solid
pka 10.16±0.40(Predicted)
color White to off-white
InChIKey HVXKQKFEHMGHSL-QKDCVEJENA-N
SMILES N(C1C=CC(Cl)=C(Cl)C=1F)C1=NC=NC2C=C(OC[C@H]3C[C@@]4([H])CN(C)C[C@@]4([H])C3)C(OC)=CC1=2 |&1:19,21,27,r|
FDA UNII F6XM2TN5A1
NCI Drug Dictionary tesevatinib

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310

XL647 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 1mg $107 2026-04-30 Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 5mg $396 2026-04-30 Buy
Cayman Chemical 27049 XL647 ≥98% 781613-23-8 10mg $740 2026-04-30 Buy
Cayman Chemical 27049 XL647 781613-23-8 1mg $97 2024-03-01 Buy
Cayman Chemical 27049 XL647 781613-23-8 10mg $672 2024-03-01 Buy
Product number Packaging Price Buy
27049 1mg $107 Buy
27049 5mg $396 Buy
27049 10mg $740 Buy
27049 1mg $97 Buy
27049 10mg $672 Buy

XL647 Chemical Properties,Uses,Production

Uses

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

Definition

ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.

in vivo

Tesevatinib (XL-647) shows potent and long-lived inhibition of the WT EGFRin vivo. Tesevatinib (XL-647) substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density[1].

IC 50

EGFR: 0.3 nM (IC50); ErbB2: 16 nM (IC50); KDR: 1.5 nM (IC50); Flt-4: 8.7 nM (IC50)

XL647 Preparation Products And Raw materials

Raw materials

Preparation Products

XL647 Suppliers

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39039 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 9951 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Jiangsu yize medical technology co. LTD 18962082606 3394205705@qq.com China 1751 58
Haiji Pharmaceutical Technology (Suzhou) Co., Ltd 18012778619 3394205705@qq.com China 9910 58
Supplier Advantage
career henan chemical co 		58
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
TargetMol Chemicals Inc. 		58
Aceschem Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Amadis Chemical Company Limited 		58
Jiangsu yize medical technology co. LTD 58
Haiji Pharmaceutical Technology (Suzhou) Co., Ltd 58

View Lastest Price from XL647 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tesevatinib pictures 2026-04-22 Tesevatinib
781613-23-8
 $109.00-482.00 99.99% 10g TargetMol Chemicals Inc.
XL-647 pictures 2019-08-08 XL-647
781613-23-8
 $3.00 1KG 99% 100kg Career Henan Chemical Co
  • Tesevatinib pictures
  • Tesevatinib
    781613-23-8
  • $109.00-482.00
  • 99.99%
  • TargetMol Chemicals Inc.
  • XL-647 pictures
  • XL-647
    781613-23-8
  • $3.00
  • 99%
  • Career Henan Chemical Co

XL647 Spectrum

XL-647(781613-23-8)1HNMR

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Tesevatinib(XL647) N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine EXEL-7647;XL-647;XL 647 KD-019 Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine XL647,Tesevatinib,EXEL 7647,KD019,HER1,Ephrin Receptor,Inhibitor,VEGFR,KD 019,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,EGFR,ErbB-1,XL 647,EXEL7647,inhibit XL647 /EXEL-7647 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]- N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine Tesevatinib, 10 mM in DMSO Tesevatinib XL-647 781613-23-8 C24H25Cl2FN4O2