2-Chloro-3-quinolinecarboxylic acid
- CAS No.
- 73776-25-7
- Chemical Name:
- 2-Chloro-3-quinolinecarboxylic acid
- Synonyms
- AKOS BBS-00007300;VITAS-BB TBB000076;RARECHEM AL BE 0745;IFLAB-BB F1973-0014;3-Carboxy-2-chloroquinoline;2-chloro-3-quinolinecarboxylate;2-chloroquinoline-3-carboxylate;2-Chloro-3-quinolinecarboxylic acid;2-CHLORO-QUINOLINE-3-CARBOXYLIC ACID;3-Quinolinecarboxylic acid, 2-chloro-
- CBNumber:
- CB7248560
- Molecular Formula:
- C10H6ClNO2
- Molecular Weight:
- 207.61
- MDL Number:
- MFCD03030039
- MOL File:
- 73776-25-7.mol
- MSDS File:
- SDS
| Melting point | 199-240 °C |
|---|---|
| Boiling point | 363.8±27.0 °C(Predicted) |
| Density | 1.469±0.06 g/cm3(Predicted) |
| storage temp. | Store at room temperature |
| pka | 2.06±0.30(Predicted) |
| form | solid |
| color | Grey |
| InChI | InChI=1S/C10H6ClNO2/c11-9-7(10(13)14)5-6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14) |
| InChIKey | XFSORZYTTCOBFN-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2)C=C(C(O)=O)C=1Cl |
| CAS DataBase Reference | 73776-25-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2933491090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-Chloro-3-quinolinecarboxylic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 688517 | 2-Chloroquinoline-3-carboxylic acid 97% | 73776-25-7 | 1g | $95 | 2023-06-20 | Buy |
| Biosynth | YCA77625 | 2-Chloro-3-quinolinecarboxylic acid | 73776-25-7 | 5g | $295 | 2026-06-05 | Buy |
| Apolloscientific | OR5757 | 2-Chloroquinoline-3-carboxylic acid 99% | 73776-25-7 | 1g | $60 | 2026-06-04 | Buy |
| Apolloscientific | OR5757 | 2-Chloroquinoline-3-carboxylic acid 99% | 73776-25-7 | 5g | $170 | 2026-06-04 | Buy |
| Apolloscientific | OR5757 | 2-Chloroquinoline-3-carboxylic acid 99% | 73776-25-7 | 25g | $763 | 2026-06-04 | Buy |
2-Chloro-3-quinolinecarboxylic acid Chemical Properties, Uses, Production
Uses
Useful quinolinecarboxylic acid for quinoline chemistry.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 32, p. 2178, 1989 DOI: 10.1021/jm00129a026
Journal of Heterocyclic Chemistry, 26, p. 1589, 1989
Synthesis
73568-25-9
73776-25-7
General procedure for the synthesis of 2-chloro-3-quinolinecarboxylic acid from 2-chloro-3-quinolinecarboxaldehyde: General method: a mixed solution of 2-chloro-3-quinolinecarboxaldehyde (0.5 mmol), tert-butylhydrogen peroxide (TBHP, 4.0 eq.), and dichloroethane (DCE, 2.0 mL) was placed under aerobic environment and heated at 80°C for 6 to 8 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the reaction mixture and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and saturated saline and subsequently dried over anhydrous sodium sulfate (Na2SO4). The organic solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by column chromatography (eluent ratio: hexane:ethyl acetate=15:5) to afford the target product 2-chloro-3-quinolinecarboxylic acid.
References
[1] Tetrahedron Letters, 2018, vol. 59, # 11, p. 1019 - 1022
[2] Green Chemistry, 2012, vol. 14, # 6, p. 1649 - 1656
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10329 - 10342
[4] Australian Journal of Chemistry, 2017, vol. 70, # 10, p. 1082 - 1092
[5] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1339 - 1340
2-Chloro-3-quinolinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-quinolinecarboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shanghai hechun co. ltd | 021-021-64502386 18017349250 | sale@syn-chem.cn | China | 268 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 2-Chloro-3-quinolinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
|
$3.00 | 1KG | 90%-99.9% | 1000kg | Career Henan Chemical Co |
-
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
73776-25-7
- $3.00
- 90%-99.9%
- Career Henan Chemical Co
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