T-butyl-3-oxocyclobutanecarboxylate
- CAS No.
- 145549-76-4
- Chemical Name:
- T-butyl-3-oxocyclobutanecarboxylate
- Synonyms
- tert-butyl 3-oxocyclobutane-1-carboxylate;T-butyl-3-oxocyclobutanecarboxylate;tert-Butyl 3-oxocyclobutanecarboxylate;tert-Butyl3-oxocyclobutanecarboxylate,97%;tert-Butyl 3-oxocyclobutanecarboxylate - [B14357];3-Oxo-cyclobutanecarboxylic acid tert-butyl ester;Cyclobutanecarboxylic acid, 3-oxo-, 1,1-diMethylethyl ester
- CBNumber:
- CB72489587
- Molecular Formula:
- C9H14O3
- Molecular Weight:
- 170.21
- MDL Number:
- MFCD12827541
- MOL File:
- 145549-76-4.mol
- MSDS File:
- SDS
| Boiling point | 230.4±33.0 °C(Predicted) |
|---|---|
| Density | 1.1g/ml |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| form | semi-solid |
| color | Colourless |
| InChI | InChI=1S/C9H14O3/c1-9(2,3)12-8(11)6-4-7(10)5-6/h6H,4-5H2,1-3H3 |
| InChIKey | JINYZTGTQXDUQR-UHFFFAOYSA-N |
| SMILES | C1(C(OC(C)(C)C)=O)CC(=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2918300090 | |||||||||
| NFPA 704 |
|
T-butyl-3-oxocyclobutanecarboxylate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR921343 | tert-Butyl 3-oxocyclobutanecarboxylate 95% | 145549-76-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR921343 | tert-Butyl 3-oxocyclobutanecarboxylate 95% | 145549-76-4 | 10g | $36 | 2026-06-04 | Buy |
| Apolloscientific | OR921343 | tert-Butyl 3-oxocyclobutanecarboxylate 95% | 145549-76-4 | 25g | $81 | 2026-06-04 | Buy |
| Synthonix | B14357 | tert-Butyl 3-oxocyclobutanecarboxylate 95+% | 145549-76-4 | 1g | $19 | 2026-05-06 | Buy |
| Synthonix | B14357 | tert-Butyl 3-oxocyclobutanecarboxylate 95+% | 145549-76-4 | 5g | $23 | 2026-05-06 | Buy |
T-butyl-3-oxocyclobutanecarboxylate Chemical Properties, Uses, Production
Synthesis
23761-23-1
75-65-0
145549-76-4
General procedure for the synthesis of tert-butyl 3-oxocyclobutanecarboxylate from 3-oxocyclobutanecarboxylic acid and tert-butanol: To a solution of commercially available 3-oxocyclobutanecarboxylic acid (11.4 g, 100 mmol) in anhydrous dichloromethane (DCM, 100 mL) was added N,N'-dicyclohexylcarbodiimide (DCC, 31 g, 150 mmol) and tert-butanol (8.9 g, 120 mmol). 120 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction was quenched with deionized water and the aqueous phase was extracted with DCM. The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product tert-butyl 3-oxocyclobutanecarboxylate (15.1 g, 89% yield).
References
[1] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[3] Journal of Organic Chemistry, 1993, vol. 58, # 1, p. 100 - 110
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 627 - 640
[5] Patent: US2009/298894, 2009, A1. Location in patent: Page/Page column 44
T-butyl-3-oxocyclobutanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Acemol Technology Co.,Ltd | 023-86822659 18611316925 | sales@acemol.com | China | 991 | 55 |
| Jiangsu Luheng Biomedical Co., Ltd. | 18936227980 | gaoweishan@lvhengchem.com | China | 128 | 58 |
| Ningbo Chemrio Chemtech Co,.Ltd. | 0574-27891269 18667892864 | frank.xiaodong@chemriotech.com | China | 3951 | 58 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 823 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from T-butyl-3-oxocyclobutanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | T-butyl-3-oxocyclobutanecarboxylate
145549-76-4
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2020-01-13 | T-butyl-3-oxocyclobutanecarboxylate
145549-76-4
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- T-butyl-3-oxocyclobutanecarboxylate
145549-76-4
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- T-butyl-3-oxocyclobutanecarboxylate
145549-76-4
- $1.00
- 99%
- Career Henan Chemical Co
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