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ChemicalBook >> CAS DataBase List >>6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one Structure
6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one structure
CAS No.
5334-35-0
Chemical Name:
6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one
Synonyms
6-chloro-1-Methyl-1H-pyrazolo[3;6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one;6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one;6-Chloro-1-methyl-1H,4H,5H-pyrazolo-[3,4-d]pyrimidin-4-one;6-chloro-1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-chloro-1,5-dihydro-1-methyl-
CBNumber:
CB72528293
Molecular Formula:
C6H5ClN4O
Molecular Weight:
184.58
MDL Number:
MFCD18793419
MOL File:
5334-35-0.mol
MSDS File:
SDS
Last updated:2026-05-28 03:51:06
Request For Quotation

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one Properties

Melting point 267-268 °C
Density 1.79±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 6.37±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FAA33435 6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one 5334-35-0 250mg $380 2026-06-04 Buy
Biosynth FAA33435 6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one 5334-35-0 2.5g $1386.5 2026-06-04 Buy
Matrix Scientific 134103 6-Chloro-1-methyl-1H,4H,5H-pyrazolo-[3,4-d]pyrimidin-4-one 5334-35-0 100.00mg $118 2026-05-18 Buy
Matrix Scientific 134103 6-Chloro-1-methyl-1H,4H,5H-pyrazolo-[3,4-d]pyrimidin-4-one 5334-35-0 500.00mg $370 2026-05-18 Buy
Matrix Scientific 134103 6-Chloro-1-methyl-1H,4H,5H-pyrazolo-[3,4-d]pyrimidin-4-one 5334-35-0 2.50g $1374 2026-05-18 Buy
Product number Packaging Price Buy
FAA33435 250mg $380 Buy
FAA33435 2.5g $1386.5 Buy
134103 100.00mg $118 Buy
134103 500.00mg $370 Buy
134103 2.50g $1374 Buy

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one Chemical Properties, Uses, Production

Synthesis

4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

98141-42-5

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one

5334-35-0

General procedure for the synthesis of 6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one from 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidinium: In a sealed reaction vessel, 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidinium (2.2 g, 10.8 mmol) and 2 M sodium hydroxide aqueous solution (50 mL). After sealing the vessel, the reaction mixture was heated to 70 °C and stirred for 30 min under the protection of a blast shield. Upon completion of the reaction, the clarified reaction solution was diluted with water and the pH was adjusted to 6-7 with 2M aqueous hydrochloric acid solution, followed by vacuum concentration. The precipitated solid was collected by filtration and washed with ethanol (~300 mL). The filtrate was concentrated in vacuum and adsorbed on Celite and purified by fast chromatography (using a 40 g silica gel column with 1-10% methanol:dichloromethane as eluent) to afford 6-chloro-1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one as a white solid (1.45 g, 72.5% yield). The product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.87 (s, 3H), 8.06 (s, 1H), 13.18 (br.s., 1H).Results of the LC-MS analysis: calculated value C6H6ClN4 [(M+H)+] 185, measured value 184.9.

References

[1] Patent: WO2013/182546, 2013, A1. Location in patent: Page/Page column 85

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one synthesis

98141-42-5
5334-35-0
Synthesis of 6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one from 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one Preparation Products And Raw materials

Raw materials

4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Sodium hydroxide Water

Preparation Products

6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one Suppliers

Global Suppliers ( 24)
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nantong Ayeschem Co., Ltd +86-513-86760116 sales@ayeschem.com China 99 58
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Shanghai YuMei Pharmaceutical Chemical Co., Ltd. 13661490451 13671802554 xyfn@163.com China 581 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Cool Pharm, Ltd 021-58581007 18019463053 sales@coolpharm.com China 9999 58
Henan Weituxi Chemical Technology Co., Ltd. 0371-63284658 18135795563 3905209149@qq.com China 9715 58
Accela ChemBio Inc. +1-858-6993322 +86-18019713315 info@accelachem.com United States 21189 58
Supplier Advantage
Accela ChemBio Co.,Ltd. 64
Nantong Ayeschem Co., Ltd 58
SPIRO PHARMA 55
Amadis Chemical Company Limited 58
Shanghai YuMei Pharmaceutical Chemical Co., Ltd. 58
Aikon International Limited 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Cool Pharm, Ltd 58
Henan Weituxi Chemical Technology Co., Ltd. 58
Accela ChemBio Inc. 58
6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one 6-chloro-1-Methyl-1H-pyrazolo[3 6-chloro-1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 6-Chloro-1-methyl-1H,4H,5H-pyrazolo-[3,4-d]pyrimidin-4-one 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-chloro-1,5-dihydro-1-methyl- 5334-35-0