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2,2-Difluorosuccinic acid

CAS No.
665-31-6
Chemical Name:
2,2-Difluorosuccinic acid
Synonyms
2,2-difluorobutanal;2,2-Difluorosuccinic acid;2,2-difluorobutanedioic acid;2,2-Difluorosuccinicacid,97%;2,2-Difluorosuccinic acid 97%;Butanedioic acid, 2,2-difluoro-;2,2-Difluorobutane-1,4-dioic acid
CBNumber:
CB7258987
Molecular Formula:
C4H4F2O4
Molecular Weight:
154.07
MDL Number:
MFCD00040970
MOL File:
665-31-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:53

2,2-Difluorosuccinic acid Properties

Melting point 144-145°C
Boiling point 127℃
Density 2.051
Flash point 113℃
storage temp. Storage temp. 2-8°C
form powder
pka 0.33±0.28(Predicted)
color Off-white
Water Solubility Soluble in water.
BRN 1773355
InChI 1S/C4H4F2O4/c5-4(6,3(9)10)1-2(7)8/h1H2,(H,7,8)(H,9,10)
InChIKey ZYLFHISLYSHWRH-UHFFFAOYSA-N
SMILES OC(=O)CC(F)(F)C(O)=O
CAS DataBase Reference 665-31-6(CAS DataBase Reference)
UNSPSC Code 12352106
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Warning
Hazard statements  H314-H318
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a
Hazard Codes  C,Xi
Risk Statements  34-36
Safety Statements  26-36/37/39-45-28-27
RIDADR  3261
WGK Germany  WGK 3
Hazard Note  Corrosive
HazardClass  8
PackingGroup  III
HS Code  2917198090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Eye Irrit. 2
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
3 0

2,2-Difluorosuccinic acid price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS002643 2,2-Difluorosuccinic acid AldrichCPR 665-31-6 50 mg $77.9 2026-04-30 Buy
Apolloscientific PC2890 2,2-Difluorosuccinic acid 95% 665-31-6 1g $66 2026-06-04 Buy
Apolloscientific PC2890 2,2-Difluorosuccinic acid 95% 665-31-6 5g $259 2026-06-04 Buy
Matrix Scientific 005615 2,2-Difluorosuccinic acid 665-31-6 250.00mg $55 2026-05-18 Buy
Matrix Scientific 005615 2,2-Difluorosuccinic acid 665-31-6 1.00g $136 2026-05-18 Buy
Product number Packaging Price Buy
CDS002643 50 mg $77.9 Buy
PC2890 1g $66 Buy
PC2890 5g $259 Buy
005615 250.00mg $55 Buy
005615 1.00g $136 Buy

2,2-Difluorosuccinic acid Chemical Properties, Uses, Production

Uses

2,2-Difluorosuccinic acid is used in the preparation of fluorofumaric acid. It is also used in enolate alkylation.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 6105, 2005 DOI: 10.1021/jo050591h

2,2-Difluorosuccinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 76)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. 023-89130144 18523560356 zhyong1011@163.com China 297 58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58

2,2-Difluorosuccinic acid Spectrum

2,2-Difluorosuccinic acid 97% 2,2-Difluorosuccinicacid,97% 2,2-difluorobutanedioic acid 2,2-Difluorobutane-1,4-dioic acid Butanedioic acid, 2,2-difluoro- 2,2-difluorobutanal 2,2-Difluorosuccinic acid 665-31-6 C4H4F2O4