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CAY10581

CAY10581 Structure
CAY10581 structure
CAS No.
1018340-07-2
Chemical Name:
CAY10581
Synonyms
CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
CBNumber:
CB72590430
Molecular Formula:
C22H21NO4
Molecular Weight:
363.41
MDL Number:
MFCD18428034
MOL File:
1018340-07-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 08:09:02
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CAY10581 Properties

Melting point 155 °C
Boiling point 548.8±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form A crystalline solid
pka 12.53±0.60(Predicted)

CAY10581 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 1mg $41 2026-04-30 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 5mg $178 2026-04-30 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 10mg $312 2026-04-30 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 25mg $680 2026-04-30 Buy
ChemScene CS-0062790 CAY10581 1018340-07-2 1mg $93 2026-06-04 Buy
Product number Packaging Price Buy
16838 1mg $41 Buy
16838 5mg $178 Buy
16838 10mg $312 Buy
16838 25mg $680 Buy
CS-0062790 1mg $93 Buy

CAY10581 Chemical Properties, Uses, Production

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

Uses

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

IC 50

IDO: 55 nM (IC50)

References

[1] SANJEEV KUMAR. Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors[J]. Journal of Medicinal Chemistry, 2008, 51 22: 7325. DOI: 10.1021/jm8013053
[2] BENJAMIN J. MOYER . Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor[J]. Toxicology and applied pharmacology, 2017, 323: Pages 74-80. DOI: 10.1016/j.taap.2017.03.012

CAY10581 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10581 Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Aladdin Scientific 58

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CAY10581 CAY10581 Exclusive 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel- 1018340-07-2