FTY720 phenoxy-biotin
- CAS No.
- Chemical Name:
- FTY720 phenoxy-biotin
- Synonyms
- FTY720 phenoxy-biotin
- CBNumber:
- CB72591053
- Molecular Formula:
- C27H45ClN4O5S
- Molecular Weight:
- 573.188
- MDL Number:
- MOL File:
- Mol file
FTY720 phenoxy-biotin price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13254 | FTY720 phenoxy-biotin ≥95% | 100μg | $37 | 2026-04-30 | Buy | |
| Cayman Chemical | 13254 | FTY720 phenoxy-biotin ≥95% | 500μg | $158 | 2026-04-30 | Buy | |
| Cayman Chemical | 13254 | FTY720 phenoxy-biotin ≥95% | 1mg | $280 | 2026-04-30 | Buy | |
| Cayman Chemical | 13254 | FTY720 phenoxy-biotin ≥95% | 5mg | $1216 | 2026-04-30 | Buy |
FTY720 phenoxy-biotin Chemical Properties, Uses, Production
Description
FTY720 is an immune modulator that down-regulates sphingosine-1-phosphate (S1P) receptors,1 enhances the activity of the sphingosine transporter ABCB1 and the leukotriene C4 transporter ABCC12 and inhibits cytosolic phospholipase A2 activity.3 It is known that some of the effects of FTY720 require its phosphorylation by sphingosine kinases in vivo, with FTY720-phosphate binding to and down-regulating S1P receptors. Biotin-FTY720 is a biotin-tagged analog of FTY720. The hydroxy methyl side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained in this analog, suggesting that it would likewise be phosphorylated in vivo.WARNING This product is not for human or veterinary use.
References
[1] V. BRINKMANN. The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*[J]. The Journal of Biological Chemistry, 2002, 10 1: 21453-21457. DOI: 10.1074/jbc.c200176200
[2] SHAUN M HONIG. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.[J]. Journal of Clinical Investigation, 2003, 111 5: 627-637. DOI: 10.1172/jci16200
[3] S. PAYNE. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.[J]. Blood, 2007, 109 3 1: 1077-1085. DOI: 10.1016/j.jaci.2006.12.597
FTY720 phenoxy-biotin Preparation Products And Raw materials
Raw materials
Preparation Products
FTY720 phenoxy-biotin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
