Methyl 3-broMo-6-chloropyrazine-2-carboxylate
- CAS No.
- 13457-28-8
- Chemical Name:
- Methyl 3-broMo-6-chloropyrazine-2-carboxylate
- Synonyms
- Methyl 3-broMo-6-chloropyrazine-2-carboxylate;3-Bromo-6-chloro-pyrazine-2-carboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 3-bromo-6-chloro-, methyl ester
- CBNumber:
- CB72595970
- Molecular Formula:
- C6H4BrClN2O2
- Molecular Weight:
- 251.47
- MDL Number:
- MFCD13195362
- MOL File:
- 13457-28-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
Methyl 3-broMo-6-chloropyrazine-2-carboxylate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 303318 | Methyl 3-bromo-6-chloropyrazine-2-carboxylate | 13457-28-8 | 1.00g | $67 | 2026-05-19 | Buy |
| Matrix Scientific | 303318 | Methyl 3-bromo-6-chloropyrazine-2-carboxylate | 13457-28-8 | 5.00g | $271 | 2026-05-19 | Buy |
| Matrix Scientific | 303318 | Methyl 3-bromo-6-chloropyrazine-2-carboxylate | 13457-28-8 | 25.00g | $1090 | 2026-05-19 | Buy |
| Synthonix | M12137 | Methyl 3-bromo-6-chloropyrazine-2-carboxylate 97.0% | 13457-28-8 | 1g | $70 | 2026-05-06 | Buy |
| Synthonix | M12137 | Methyl 3-bromo-6-chloropyrazine-2-carboxylate 97.0% | 13457-28-8 | 5g | $290 | 2026-05-06 | Buy |
Methyl 3-broMo-6-chloropyrazine-2-carboxylate Chemical Properties, Uses, Production
Uses
Methyl 3-broMo-6-chloropyrazine-2-carboxylate is an important intermediate for the synthesis of a class of antitumour drugs, SHP2 inhibitors, which can be used in the pharmaceutical development process.
Synthesis
1458-03-3
13457-28-8
The general procedure for the synthesis of methyl 3-bromo-6-chloropyrazine-2-carboxylate from methyl 3-amino-6-chloropyrazine-2-carboxylate was as follows: 100 mL of acetic acid was added to a 500 mL three-necked flask and cooled to 0 °C. Methyl 3-amino-6-chloropyrazine-2-carboxylate (20 g, 0.11 mol) was slowly added dropwise to 100 mL of aqueous hydrogen bromide solution at 0 °C. The dropwise addition process was continued for 30 min to ensure complete reaction. Subsequently, 50 mL of aqueous sodium nitrite (20.7 g, 0.33 mol) was slowly added dropwise while maintaining 0°C. After 30 minutes of reaction, the completion of the reaction was confirmed and 30 mL of 10% sodium bisulfite solution was added to terminate the reaction. The reaction mixture was extracted with ethyl acetate (200 mL x 2 times), the organic phases were combined and dried with 20 g of anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give methyl 3-bromo-6-chloropyrazine-2-carboxylate (23.3 g, 87% yield) as a white solid.
References
[1] Patent: CN108101857, 2018, A. Location in patent: Paragraph 0035-0037
Methyl 3-broMo-6-chloropyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-broMo-6-chloropyrazine-2-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 974 | 65 |
| Kohn & Shawn Pharmatech Co.,Ltd | 0943-8293106 | sales@kyxpharma.com | China | 297 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Nanjing Duolong Bio-tech Co.,Ltd. | 18905173768 | 52513593@qq.com | China | 2337 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai Boyners Pharm-Tech Co., Ltd. | 13817873692 | mkt@boynerspharm.com | China | 1707 | 55 |
