methyl 6-amino-3,5-dibromopicolinate
- CAS No.
- 443956-21-6
- Chemical Name:
- methyl 6-amino-3,5-dibromopicolinate
- Synonyms
- methyl 6-amino-3,5-dibromopicolinate;Methyl 6-aMino-3,5-dibroMopyridine-2-carboxylate;6-Amino-3,5-dibromopyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-amino-3,5-dibromo-, methyl ester
- CBNumber:
- CB22535876
- Molecular Formula:
- C7H6Br2N2O2
- Molecular Weight:
- 309.94
- MDL Number:
- MFCD13195771
- MOL File:
- 443956-21-6.mol
- MSDS File:
- SDS
methyl 6-amino-3,5-dibromopicolinate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M45233 | Methyl 6-amino-3,5-dibromopicolinate 95+% | 443956-21-6 | 100mg | $26 | 2026-05-06 | Buy |
| Synthonix | M45233 | Methyl 6-amino-3,5-dibromopicolinate 95+% | 443956-21-6 | 250mg | $30 | 2026-05-06 | Buy |
| Synthonix | M45233 | Methyl 6-amino-3,5-dibromopicolinate 95+% | 443956-21-6 | 1g | $32 | 2026-05-06 | Buy |
| Synthonix | M45233 | Methyl 6-amino-3,5-dibromopicolinate 95+% | 443956-21-6 | 5g | $140 | 2026-05-06 | Buy |
| Synthonix | M45233 | Methyl 6-amino-3,5-dibromopicolinate 95+% | 443956-21-6 | 25g | $540 | 2026-05-06 | Buy |
methyl 6-amino-3,5-dibromopicolinate Chemical Properties, Uses, Production
Uses
Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate is used as a reagent in the synthesis of imidazopyridines as Syk inhibitors. Also used as a reagent in the synthesis of quinoline, quinoxaline and naphthyridine derivatives as antibacterial agents.
Synthesis
36052-26-3
443956-21-6
178876-83-0
178876-82-9
General procedure for the synthesis of methyl 6-amino-3,5-dibromopyridine-2-carboxylate, methyl 6-amino-3-bromopyridine-2-carboxylate, and methyl 5-bromo-6-aminopyridine-2-carboxylate from methyl 6-aminopyridine-2-carboxylate: over a period of 30 min, a solution of chloroform (40 mL) with bromine (2.57 mL) was added slowly and dropwise to methyl 6-aminopyridine-2-carboxylate ( 6.92 g) in a solution of chloroform (300 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was upsampled onto a silica gel column and purified by column chromatography (SiO2, heptane/ethyl acetate) to isolate three products: methyl 6-amino-5-bromo-pyridine-2-carboxylate (2 g, 19% yield), methyl 6-amino-3-bromo-pyridine-2-carboxylate (3 g, 29% yield) and methyl 6-amino-3,5-dibromopyridine-2-carboxylate (2.6 g, 18% yield).The 1H NMR (400 MHz, chloroform-d) data for methyl 6-amino-5-bromopyridine-2-carboxylate were as follows: δ 3.97 (s, 3H), 5.22 (br.s, 2H), 7.38 (d, J = 7.8 Hz, 1H), 7.79 (d, J = 7.8 Hz, 1H).
References
[1] Patent: WO2011/75591, 2011, A1. Location in patent: Page/Page column 95
[2] Patent: US2011/152312, 2011, A1. Location in patent: Page/Page column 40
methyl 6-amino-3,5-dibromopicolinate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Wuhan Luohua Medical Technology Co.,Ltd. | 13477084141; 13477084141 | sales@luohuapharm.com | China | 468 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Wuxi Zhangkun Biochemical Technology Co., Ltd. | +86 0510-85629785 | China | 2321 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4563 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
View Latest Price from methyl 6-amino-3,5-dibromopicolinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | methyl 6-amino-3,5-dibromopicolinate
443956-21-6
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
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- methyl 6-amino-3,5-dibromopicolinate
443956-21-6
- $1.00
- 99%
- Career Henan Chemical Co
