BNC105
- CAS No.
- 945771-74-4
- Chemical Name:
- BNC105
- Synonyms
- BNC105;CS-2127;BNC105, 10 mM in DMSO;inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin;6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol;2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan;(7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone;Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-
- CBNumber:
- CB72627624
- Molecular Formula:
- C20H20O7
- Molecular Weight:
- 372.37
- MDL Number:
- MFCD22628798
- MOL File:
- 945771-74-4.mol
| Melting point | 156-158 °C(Solv: methanol (67-56-1)) |
|---|---|
| Boiling point | 529.3±50.0 °C(Predicted) |
| Density | 1.261±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:25.0(Max Conc. mg/mL);67.14(Max Conc. mM) |
| form | A solid |
| pka | 6.60±0.50(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | Z3S2Z6H7B0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BNC105 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-4191 | BNC105 99.49% | 945771-74-4 | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-4191 | BNC105 99.49% | 945771-74-4 | 5mg | $330 | 2021-12-16 | Buy |
| Crysdot | CD31000118 | BNC105 98+% | 945771-74-4 | 10mg | $347 | 2021-12-16 | Buy |
| Crysdot | CD31000118 | BNC105 98+% | 945771-74-4 | 5mg | $243 | 2021-12-16 | Buy |
| Crysdot | CD31000118 | BNC105 98+% | 945771-74-4 | 50mg | $1042 | 2021-12-16 | Buy |
BNC105 Chemical Properties,Uses,Production
Uses
BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
References
[1] Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. DOI:10.1021/jm200454y
[2] Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. DOI:10.1158/1535-7163.MCT-09-0815
[3] Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60. DOI:10.4161/15384047.2014.956605
BNC105 Preparation Products And Raw materials
Raw materials
Preparation Products
BNC105 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32433 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +852-852-95427495 +85295427495 | kathy@hbyinsheng.com | China | 3512 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
