BNC105 manufacturers
- BNC105
-
- $76.00
-
2026-04-20
- CAS:945771-74-4
- Purity: 96.57%
- Supply Ability: 10g
- BNC105
-
- $76.00
-
2026-04-20
- CAS:945771-74-4
- Purity: 96.57%
- Supply Ability: 10g
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| Product Name: | BNC105 | | Synonyms: | BNC105;2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan;CS-2127;Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)-;(7-Hydroxy-6-methoxy-2-methylbenzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone;inhibit,Inhibitor,BNC 105,BNC105,BNC-105,Microtubule/Tubulin;6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol;BNC105, 10 mM in DMSO | | CAS: | 945771-74-4 | | MF: | C20H20O7 | | MW: | 372.37 | | EINECS: | | | Product Categories: | | | Mol File: | 945771-74-4.mol |  |
| | BNC105 Chemical Properties |
| Melting point | 156-158 °C(Solv: methanol (67-56-1)) | | Boiling point | 529.3±50.0 °C(Predicted) | | density | 1.261±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:25.0(Max Conc. mg/mL);67.14(Max Conc. mM) | | form | A solid | | pka | 6.60±0.50(Predicted) | | color | Light yellow to yellow |
| | BNC105 Usage And Synthesis |
| Uses | BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. | | References | [1] Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. DOI:10.1021/jm200454y
[2] Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. DOI:10.1158/1535-7163.MCT-09-0815
[3] Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60. DOI:10.4161/15384047.2014.956605 |
| | BNC105 Preparation Products And Raw materials |
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