Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
![Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Structure](CAS/20150408/GIF/1333210-07-3.gif)
- CAS No.
- 1333210-07-3
- Chemical Name:
- Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
- Synonyms
- SAR7334;TRCP6-IN-1;TRCP6 inhibitor;SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels;4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile;Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-
- CBNumber:
- CB72668052
- Molecular Formula:
- C21H22ClN3O
- Molecular Weight:
- 367.87
- MDL Number:
- MOL File:
- 1333210-07-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| SAR7334 ≥98%(HPLC) | 5831 | 5 | $283 |
| SAR7334 99.91% | CS-3902 | 5mg | $230 |
| SAR7334 | B1189 | 2mg | $326 |
| SAR7334 99.91% | CS-3902 | 10mg | $400 |
| SAR7334 | B1189 | 5mg | $488 |
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Properties
| Boiling point | 534.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO |
| form | Solid |
| pka | 10.95±0.20(Predicted) |
| color | Light yellow to yellow |
| InChIKey | RLKRLNQEXBPQGQ-OZOXKJRCSA-N |
| SMILES | Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5831 | SAR7334 ≥98%(HPLC) | 1333210-07-3 | 5 | $283 | 2021-12-16 | Buy |
| ChemScene | CS-3902 | SAR7334 99.91% | 1333210-07-3 | 5mg | $230 | 2021-12-16 | Buy |
| ApexBio Technology | B1189 | SAR7334 | 1333210-07-3 | 2mg | $326 | 2021-12-16 | Buy |
| ChemScene | CS-3902 | SAR7334 99.91% | 1333210-07-3 | 10mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | B1189 | SAR7334 | 1333210-07-3 | 5mg | $488 | 2021-12-16 | Buy |
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Chemical Properties,Uses,Production
Uses
SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
Biological Activity
sar7334 is a potent trpc6(transient receptor potential cation channel, subfamily c, member 6) inhibitor.
in vivo
SAR7334 (10mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].
References
[1] Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. DOI:10.1038/s41598-017-00406-2
[2] Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. DOI:10.3389/fphar.2016.00486
[3] Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. DOI:10.1111/bph.13151
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19957 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 39999 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
