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PF 04554878 hydrochloride

PF 04554878 hydrochloride Structure
PF 04554878 hydrochloride structure
CAS No.
1073160-26-5
Chemical Name:
PF 04554878 hydrochloride
Synonyms
Defactinib hydrochloride;VS6063 hydrochloride;VS 6063 hydrochloride;VS-6063 hydrochloride;Defactinib hydrochlorid;Defactinib (VS-6063) HCl;PF04554878 hydrochloride;PF-04554878 hydrochloride;PF 04554878 hydrochloride;VS60Chemicalbook63hydrochloride
CBNumber:
CB72729359
Molecular Formula:
C20H21F3N8O3S.ClH
Molecular Weight:
546.96
MDL Number:
MFCD28144730
MOL File:
1073160-26-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:57:00
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PF 04554878 hydrochloride Properties

storage temp. Store at -20°C
solubility DMSO:30.0(Max Conc. mg/mL);54.85(Max Conc. mM)
form Solid
color White to off-white
InChIKey RCHQNUQAHJNRBY-UHFFFAOYSA-N
SMILES N(C1=NC(NC2C=CC(C(=O)NC)=CC=2)=NC=C1C(F)(F)F)CC1=NC=CN=C1N(C)S(=O)(=O)C.Cl
FDA UNII L2S469LM49

PF 04554878 hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth YSB16026 Defactinib hydrochloride 1073160-26-5 50mg $828.5 2026-06-05 Buy
Biosynth YSB16026 Defactinib hydrochloride 1073160-26-5 100mg $1325 2026-06-05 Buy
ChemScene CS-3411 Defactinib hydrochloride 99.35% 1073160-26-5 5mg $91 2026-06-04 Buy
ChemScene CS-3411 Defactinib hydrochloride 99.35% 1073160-26-5 10mg $117 2026-06-04 Buy
ChemScene CS-3411 Defactinib hydrochloride 99.35% 1073160-26-5 25mg $208 2026-06-04 Buy
Product number Packaging Price Buy
YSB16026 50mg $828.5 Buy
YSB16026 100mg $1325 Buy
CS-3411 5mg $91 Buy
CS-3411 10mg $117 Buy
CS-3411 25mg $208 Buy

PF 04554878 hydrochloride Chemical Properties, Uses, Production

Uses

Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

in vivo

Defactinib (VS-6063) doses of 25 mg/kg twice a day or greater statistically significantly inhibits pFAK (Tyr397) at 3 hours, with return of expression noted by 24 hours. Therefore, administration of Defactinib at 25 mg/kg twice a day is selected as the dosing schedule for subsequent therapy experiments. For therapy experiments, female nude mice bearing HeyA8 tumors in the peritoneal cavity are randomly divided into 4 groups (n=10 per group): 1) vehicle orally twice daily and phosphate-buffered saline intraperitoneally weekly (control); 2) Defactinib 25 mg/kg orally twice daily; 3) PTX intraperitoneally weekly; and 4) both VDefactinib 25 mg/kg orally twice daily and PTX intraperitoneally weekly. There is an 87.4% reduction in tumor weight by PTX monotherapy in the HeyA8 model, and combination therapy resulted in the greatest tumor weight reduction, with a 97.9% reduction (P=0.05 compared with PTX). In the SKOV3ip1 model, a 92.7% tumor weight reduction is observed in the combination group compared with PTX (P<0.001)[1].

References

[1] Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. DOI:10.1093/jnci/djt210

PF 04554878 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

PF 04554878 hydrochloride Suppliers

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
Deyang Sino Biotech. Co., LTD +86-19182167371 service@synlord.com China 110 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2959 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Supplier Advantage
Deyang Sino Biotech. Co., LTD 58
Bide Pharmatech Ltd. 60
LETOPHARM LIMITED 58
Shanghai YuanQi Biotechnology Co., Ltd. 50
Shanghaizehan biopharma technology co., Ltd. 55
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58

View Latest Price from PF 04554878 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Defactinib hydrochlorid pictures 2020-01-02 Defactinib hydrochlorid
1073160-26-5
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

PF 04554878 hydrochloride Spectrum

PF 04554878 hydrochloride(1073160-26-5)1HNMR

1073160-26-5 (PF 04554878 hydrochloride) Related Search:

Defactinib ODM-201 2-Propynamide, N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]- PF-562271 PF 04554878 hydrochloride
MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

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PF 04554878 hydrochloride PF04554878 hydrochloride PF-04554878 hydrochloride VS 6063 hydrochloride VS6063 hydrochloride VS-6063 hydrochloride Defactinib( VS-6063,PF-04554878 ) hydrochloride Defactinib HCl salt,VS-6063 HCl salt, PF-04554878 HCl salt Defactinib hydrochloride (VS-6063, PF-04554878) Defactinib (VS-6063) HCl Defactinib hydrochloride (VS-6063, PF-04554878) HCl Defactinib (VS-6063) hydrochloride N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide,hydrochloride Defactinib hydrochlorid VS60Chemicalbook63hydrochloride N-Methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide hydrochloride Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-, hydrochloride (1:1) Defactinib hydrochloride (VS-6063 Defactinib hydrochloride 1073160-26-5 API