N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- CAS No.
- 945128-26-7
- Chemical Name:
- N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
- Synonyms
- ML249;CYM5541;CYM-5541;CID-17253208;CYM 5541(ML-249);CYM-5541, 10 mM in DMSO;CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N,N-dicyclohexyl-5-cyclopropyl-
- CBNumber:
- CB72750683
- Molecular Formula:
- C19H28N2O2
- Molecular Weight:
- 316.44
- MDL Number:
- MFCD09782785
- MOL File:
- 945128-26-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 503.1±38.0 °C(Predicted) |
|---|---|
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | -2.57±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | 1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2 |
| InChIKey | NDKGACIWVAOUQH-UHFFFAOYSA-N |
| SMILES | N(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2 |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0680 | CYM-5541 ≥98% (HPLC) | 945128-26-7 | 5mg | $115 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0680 | CYM-5541 ≥98% (HPLC) | 945128-26-7 | 25mg | $306.85 | 2026-04-30 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 5mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 10mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 15190 | CYM 5541 ≥98% | 945128-26-7 | 25mg | $233 | 2026-04-30 | Buy |
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemical Properties,Uses,Production
Description
The sphingosine 1-
Uses
CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
Biochem/physiol Actions
CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.
storage
Store at +4°C
References
[1] Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program
[2] EUIJUNG JO. Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor[J]. ACS Chemical Biology, 2012, 7 12: 1975-1983. DOI:10.1021/cb300392z
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 10000 | 58 |
