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1374107-46-6

1374107-46-6 Structure
1374107-46-6 structure
CAS No.
1374107-46-6
Chemical Name:
1374107-46-6
Synonyms
1-[2-[4-(Dimethylamino)phenyl]quinolin-6-yl]oxy-3-fluoropropan-2-ol;2-Propanol, 1-[[2-[4-(dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro-
CBNumber:
CB73049236
Molecular Formula:
C20H21FN2O2
Molecular Weight:
340.39
MDL Number:
MFCD29767867
MOL File:
1374107-46-6.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
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1374107-46-6 Properties

Boiling point 545.5±50.0 °C(Predicted)
Density 1.213±0.06 g/cm3(Predicted)
pka 12.84±0.20(Predicted)

1374107-46-6 Chemical Properties, Uses, Production

Uses

THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5105 hasthepotential to act as a tau imaging PET probe[1].

References

[1] Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7. DOI:10.2967/jnumed.112.117341

1374107-46-6 synthesis

1587709-90-7
1374107-46-6
Synthesis of 1374107-46-6 from 1587709-90-7

1374107-46-6 Preparation Products And Raw materials

Raw materials

Preparation Products

1374107-46-6 Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589 3321478047@qq.com China 2002 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com China 32997 60
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 55
Amadis Chemical Company Limited 58
TargetMol Chemicals Inc. 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58

View Latest Price from 1374107-46-6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
THK-5105 pictures 2026-04-20 THK-5105
1374107-46-6
 $2140.00-3520.00 10g TargetMol Chemicals Inc.
  • THK-5105 pictures
  • THK-5105
    1374107-46-6
  • $2140.00-3520.00
  • TargetMol Chemicals Inc.

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2-Propanol, 1-[[2-[4-(dimethylamino)phenyl]-6-quinolinyl]oxy]-3-fluoro- 1-[2-[4-(Dimethylamino)phenyl]quinolin-6-yl]oxy-3-fluoropropan-2-ol 1374107-46-6