tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate
- CAS No.
- 1006875-83-7
- Chemical Name:
- tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate
- Synonyms
- 2-methylthiazole-11-carboxylic acid;Oxirane, 2-[9-(phenylMethoxy)ethyl]-;1-[2-(tert-Butoxy)-2-oxoethyl]-1H-pyrazole-4-boronic Acid Pinacol Ester;tert-butyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetate;tert-butyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate;tert-butyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate;tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate;tert-butyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate - [T15958];1H-Pyrazole-1-acetic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB73066862
- Molecular Formula:
- C15H25BN2O4
- Molecular Weight:
- 308.18
- MDL Number:
- MFCD22570725
- MOL File:
- 1006875-83-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 291790 | tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate | 1006875-83-7 | 1.00g | $98 | 2026-05-19 | Buy |
| Matrix Scientific | 291790 | tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate | 1006875-83-7 | 5.00g | $336 | 2026-05-19 | Buy |
| Matrix Scientific | 291790 | tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate | 1006875-83-7 | 10.00g | $660 | 2026-05-19 | Buy |
| Synthonix | T15958 | tert-butyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate 97.0% | 1006875-83-7 | 100mg | $38 | 2026-05-06 | Buy |
| Synthonix | T15958 | tert-butyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate 97.0% | 1006875-83-7 | 250mg | $44 | 2026-05-06 | Buy |
tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Chemical Properties, Uses, Production
Uses
tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate is used as a reactant in the preparation of imidazotriazines and imidazopyrimidines as kinase inhibitors.
Synthesis
269410-08-4
5292-43-3
1006875-83-7
Using 4-pyrazoleboronic acid pinacol ester (2.0 g, 10.31 mmol) and tert-butyl bromoacetate (2.212 g, 11.34 mmol) as the raw material, the mixture was reacted with potassium carbonate (1.709 g, 12.37 mmol) in acetone (20 mL) for 13 h at 65 °C with stirring under nitrogen protection. Upon completion of the reaction, the reaction mixture was poured into ice water (20 mL) and extracted with ethyl acetate (50 mL × 2). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 5/1) to afford the target compound tert-butyl 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate (3 g, 8.76 mmol, 85% yield) as an oil. lC-MS (Method C): m/z 309.2 ([M+H]+), retention time: 1.946 min; 1H NMR (400 MHz, CDCl3) δ 7.82 (s, 1H), 7.75 (s, 1H), 4.82 (s, 2H), 1.47 (s, 9H), 1.28 (s, 12H).
References
[1] Patent: WO2016/123796, 2016, A1. Location in patent: Page/Page column 49; 50
[2] Patent: US2008/39457, 2008, A1. Location in patent: Page/Page column 36
[3] Patent: US2013/59835, 2013, A1. Location in patent: Paragraph 1146
[4] Patent: US2014/249132, 2014, A1. Location in patent: Paragraph 0424
[5] Patent: US2010/240634, 2010, A1. Location in patent: Page/Page column 57-58
tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15574813303 | luxingbc@126.com | China | 1975 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Taian Jiaye Biotechnology Co.Ltd | 15318151873;13127280945 | 285424065@qq.com | China | 9961 | 55 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Shanghai SPAR pharmaceutical technology co., LTD | 021-000000 | admin@jingshipharmatech.com | China | 9919 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
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