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1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Structure
1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester structure
CAS No.
864754-16-5
Chemical Name:
1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester
Synonyms
ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate;ethyl 2-(4-(4,4,5,5-tet;1-(Ethoxycarbonylmethyl)-1H<;1-(Ethoxycarbonylmethyl)pyrazole-4-boronic Acid Pin;1-(Ethoxycarbonylmethyl)pyrazole-4-boronic Acid Pinacol Ester;ethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-py...;1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester;1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester 97%;1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester;ethyl 2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate
CBNumber:
CB3836680
Molecular Formula:
C13H21BN2O4
Molecular Weight:
280.13
MDL Number:
MFCD08706026
MOL File:
864754-16-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:13
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1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Properties

Boiling point 390.8±22.0 °C(Predicted)
Density 1.12±0.1 g/cm3(Predicted)
refractive index n20/D 1.4814
Flash point 110 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form liquid
pka 1.49±0.10(Predicted)
Appearance Light yellow to yellow Liquid
InChI 1S/C13H21BN2O4/c1-6-18-11(17)9-16-8-10(7-15-16)14-19-12(2,3)13(4,5)20-14/h7-8H,6,9H2,1-5H3
InChIKey YUEZJHOSHBTWPV-UHFFFAOYSA-N
SMILES CCOC(=O)Cn1cc(cn1)B2OC(C)(C)C(C)(C)O2
UNSPSC Code 12352103
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2933199090
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 683566 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester 97% 864754-16-5 1g $143 2026-04-30 Buy
Sigma-Aldrich 683566 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester 97% 864754-16-5 250mg $63.8 2023-01-07 Buy
Apolloscientific OR302124 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97% 864754-16-5 250mg $21 2026-06-04 Buy
Apolloscientific OR302124 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97% 864754-16-5 1g $25 2026-06-04 Buy
Apolloscientific OR302124 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97% 864754-16-5 5g $86 2026-06-04 Buy
Product number Packaging Price Buy
683566 1g $143 Buy
683566 250mg $63.8 Buy
OR302124 250mg $21 Buy
OR302124 1g $25 Buy
OR302124 5g $86 Buy

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Chemical Properties, Uses, Production

Chemical Properties

liquid

Uses

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester

Synthesis

Ethyl 2-(4-broMo-1H-pyrazol-1-yl)acetate

82231-58-1

Bis(pinacolato)diboron

73183-34-3

1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER

864754-16-5

The general procedure for the synthesis of 1-(ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester from ethyl 4-bromo-1H-pyrazole-1-acetate and bis-boronic acid pinacol ester was carried out as follows: firstly, 4,4,5,5-tetramethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaboro Heterocyclopentane (436 mg, 1.72 mmol) was dissolved in DMF (10 mL). Subsequently, KOAc (420 mg, 4.29 mmol) and Pd(dppf)Cl2-CH2Cl2 (35 mg, 0.043 mmol) were added sequentially. The reaction mixture was heated to 80 °C and a solution of ethyl 4-bromo-1H-pyrazole-1-acetate (333 mg, 1.43 mmol) in DMF (10 mL) was added dropwise at this temperature. The reaction mixture was stirred at 80 °C overnight and then evaporated to dryness. Finally, the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 1:10) to afford the target product 1-(ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester (76 mg, 19% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 52
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 21, p. 6804 - 6820

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Preparation Products And Raw materials

Raw materials

Ethyl 2-(4-broMo-1H-pyrazol-1-yl)acetate Bis(pinacolato)diboron Potassium Acetate N,N-Dimethylformamide

Preparation Products

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Suppliers

Global Suppliers ( 101)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Runpharm Technology Limited 18171398856 2968382473 service@runpharm.com China 716 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Thermo Fisher Scientific 75
Shanghai Topbiochem Technology Co., Ltd 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Runpharm Technology Limited 55

View Latest Price from 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate pictures 2026-08-25 ethyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate
864754-16-5
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER pictures 2021-07-13 1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
864754-16-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER pictures 2021-07-10 1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER
864754-16-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester Spectrum

1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER(864754-16-5)1HNMR

864754-16-5 (1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester) Related Search:

1H-Pyrazole-4-boronic acid 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester 4-Pyrazoleboronic acid pinacol ester 1-Methyl-4-pyrazole boronic acid pinacol ester
1-Methyl-1H-pyrazole-4-boronic acid

1of2

[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YL]-ACETIC ACID ETHYL ESTER ethyl 2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate 1-(Ethoxycarbonylmethyl)pyrazole-4-boronic Acid Pinacol Ester 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester 97% Ethyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetate 1H-Pyrazole-1-acetic acid,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-,ethyl ester 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester ethyl 2-(4-(4,4,5,5-tet 1-(Ethoxycarbonylmethyl)pyrazole-4-boronic Acid Pin ethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate ethyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-py... 1-(Ethoxycarbonylmethyl)-1H< ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate 1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 864754-16-5 Boronate Esters Boronic Acids and Derivatives Chemical Synthesis Heteroaryl Boronate Esters Organometallic Reagents