Chrysin
- CAS No.
- 480-40-0
- Chemical Name:
- Chrysin
- Synonyms
- 5,7-DIHYDROXYFLAVONE;5,7-Dihydroxy-2-phenyl-4H-chromen-4-one;Crysin;CHRYSINE;5,7-DIHYDROXY-2-PHENYL-CHROMEN-4-ONE;hrysin;CHRYSIN;NSC 407436;Chrysin-RM;CHRYSIN(RG)
- CBNumber:
- CB7312472
- Molecular Formula:
- C15H10O4
- Molecular Weight:
- 254.24
- MDL Number:
- MFCD00006834
- MOL File:
- 480-40-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 284-286 °C(lit.) |
|---|---|
| Boiling point | 357.45°C (rough estimate) |
| Density | 1.2693 (rough estimate) |
| refractive index | 1.4872 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | 6.50±0.40(Predicted) |
| color | Yellow |
| λmax | 348 nm |
| Merck | 14,2256 |
| BRN | 233276 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H |
| InChIKey | RTIXKCRFFJGDFG-UHFFFAOYSA-N |
| SMILES | Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3 |
| LogP | 3.520 |
| CAS DataBase Reference | 480-40-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 3CN01F5ZJ5 |
| UNSPSC Code | 85151701 |
| NACRES | NA.47 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LK8329050 | |||||||||
| F | 10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Chrysin price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C80105 | Chrysin 97% | 480-40-0 | 25g | $172 | 2026-04-30 | Buy |
| Sigma-Aldrich | 95082 | Chrysin analytical standard | 480-40-0 | 50mg | $143 | 2026-04-30 | Buy |
| TCI Chemical | C1652 | Chrysin >98.0%(HPLC)(T) | 480-40-0 | 25g | $78 | 2026-04-30 | Buy |
| Cayman Chemical | 17402 | Chrysin ≥95% | 480-40-0 | 5g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17402 | Chrysin ≥95% | 480-40-0 | 10g | $61 | 2026-04-30 | Buy |
Chrysin Chemical Properties,Uses,Production
Description
Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.
Chemical Properties
beige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.
Uses
Chrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand with possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that. Dyes and metabolites.
Definition
ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.
Biological Functions
Chrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi. It holds immense potential for diverse applications and is being investigated as a potential therapeutic agent for various conditions and diseases. Research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. Its therapeutic potential extends to areas like oncology, diabetes, and neurological disorders. Although the precise mechanism of action of chrysin is not yet fully comprehended, research suggests its ability to modulate the activity of enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis.
target
NOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad
Source
The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.
References
[1] KYUNG JIN WOO. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity[J]. FEBS Letters, 2005, 579 3: 705-711. DOI: 10.1016/j.febslet.2004.12.048
[2] HARRIS GABRIEL K . Luteolin and Chrysin Differentially Inhibit Cyclooxygenase-2 Expression and Scavenge Reactive Oxygen Species but Similarly Inhibit Prostaglandin-E2 Formation in RAW 264.7 Cells1[J]. Journal of Nutrition, 2006, 136 6: Pages 1517-1521. DOI: 10.1093/jn/136.6.1517
[3] BEIBEI FU. Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.[J]. Molecular Cancer Therapeutics, 2007, 6 1: 220-226. DOI: 10.1158/1535-7163.mct-06-0526
[4] YANG YAO. Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation.[J]. International Journal of Molecular Sciences, 2014, 15 11: 20913-20926. DOI: 10.3390/ijms151120913
Chrysin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FST Pharmaceutical Co., Ltd | 0571-88938510 18667135863 | ld@highfine.com | China | 189 | 60 |
| Shanxi Yuning Biotechnology Co., Ltd. | 13623677056 | 1039999500@qq.com | China | 511 | 58 |
| Qi Qi hang Biotechnology Co., Ltd. | 18151111370 | 1046215251@qq.com | China | 5999 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Xinxiang Baixin Chemical Co. LTD | 15076321805 13373512662 | 15073621805@qq.com | China | 11 | 58 |
| Xi'an Hongtaiyuan Biotechnology Co., Ltd | 15829065593; 15829065593 | hty15829065593@qq.com | China | 168 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
Related articles
- Chrysin: Pharmacokinetics and Pharmacological Activities
- Chrysin, a flavonoid with low bioavailability, shows diverse pharmacological activities and therapeutic potential, warranting ....
- Sep 19,2024
- Introduction and Pharmacological action of Chrysin
- Lutein is a dihydroxyflavonoid with anti-inflammatory, antineoplastic, antioxidant, hepatoprotective, antihypertensive, antivi....
- Aug 25,2022
View Lastest Price from Chrysin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Chrysin
480-40-0
|
$80.00 | 1kg | 98% 99% | 100000 | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2026-09-11 | Chrysin
480-40-0
|
1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-25 | Chrysin
480-40-0
|
1kg | 98% | 888kgs | Xi an Biohorlden Industry Trade Co Ltd |
