PHCCC
- CAS No.
- 179068-02-1
- Chemical Name:
- PHCCC
- Synonyms
- (-) PHCCC;PHCCC >=97% (HPLC);PHCCC, 10 mM in DMSO;PHCCC, allosteric potentiator at mGlu4;(7Z)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide;7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide;7,7a-Dihydro-7-(hydroxyimino)-N-phenylbenzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide;Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-;Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide,7,7a-dihydro-7-(hydroxyimino)-N-phenyl-,(7Z)-;allosteric,disease,Metabotropic glutamate receptors,Inhibitor,PHCCC,neurons,neuroprotective,mGluR,Parkinson's,inhibit
- CBNumber:
- CB73128919
- Molecular Formula:
- C17H14N2O3
- Molecular Weight:
- 294.3
- MDL Number:
- MOL File:
- 179068-02-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PHCCC 99.92% | CS-5719 | 5mg | $76 |
| PHCCC 99.92% | CS-5719 | 10mg | $125 |
| PHCCC 99.92% | CS-5719 | 25mg | $271 |
| PHCCC 99.92% | CS-5719 | 50mg | $433 |
| PHCCC 99.92% | CS-5719 | 100mg | $650 |
| More product size | |||
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Powder |
| color | White to off-white |
| InChI | 1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15+ |
| InChIKey | FPXPIEZPAXSELW-XDJHFCHBSA-N |
| SMILES | O=C(NC1=CC=CC=C1)C2(C/3C2)OC4=C(C=CC=C4)C3=N/O |
| FDA UNII | 875PGG7NBA |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311-H320-H370 |
| Precautionary statements | P501-P260-P270-P264-P280-P337+P313-P305+P351+P338-P308+P311-P361+P364-P301+P310+P330-P302+P352+P312-P405 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
PHCCC price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5719 | PHCCC 99.92% | 179068-02-1 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-5719 | PHCCC 99.92% | 179068-02-1 | 10mg | $125 | 2026-06-04 | Buy |
| ChemScene | CS-5719 | PHCCC 99.92% | 179068-02-1 | 25mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-5719 | PHCCC 99.92% | 179068-02-1 | 50mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-5719 | PHCCC 99.92% | 179068-02-1 | 100mg | $650 | 2026-06-04 | Buy |
PHCCC Chemical Properties,Uses,Production
Uses
PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[1][2].
Definition
ChEBI: 7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b][1]benzopyran-1a-carboxamide is a 1-benzopyran.
Biological Activity
PHCCC is a positive allosteric modulator (PAM) at the mGluR4 subtype th at exhibits anxiolytic and anti-Parkinsonian effects in animal models. PHCCC is a potent group I metabotropic glutamate receptor antagonist.
in vivo
PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model[2].
IC 50
Group I mGluR receptors: 3 μM (IC50)
storage
Store at RT
References
[1] Récasens M, et al. Metabotropic glutamate receptors as drug targets. Curr Drug Targets. 2007;8(5):651-681. DOI:10.2174/138945007780618544
[2] Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. DOI:10.1073/pnas.1835724100
PHCCC Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10457 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9945 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 |
