BAY-1125976.
- CAS No.
- 1402608-02-9
- Chemical Name:
- BAY-1125976.
- Synonyms
- CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;BAY1125976, 10 mM in DMSO;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
- CBNumber:
- CB73133467
- Molecular Formula:
- C23H21N5O
- Molecular Weight:
- 383.45
- MDL Number:
- MFCD30481340
- MOL File:
- 1402608-02-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) |
| form | A crystalline solid |
| color | Light yellow to yellow |
| InChI | InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29) |
| InChIKey | JBGYKRAZYDNCNV-UHFFFAOYSA-N |
| SMILES | C12=NC(C3=CC=C(C4(N)CCC4)C=C3)=C(C3=CC=CC=C3)N1N=C(C(N)=O)C=C2 |
| FDA UNII | ZL7A1UM87X |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BAY-1125976. price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28913 | BAY-1125976 ≥98% | 1402608-02-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 ≥98% | 1402608-02-9 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 ≥98% | 1402608-02-9 | 10mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 ≥98% | 1402608-02-9 | 25mg | $587 | 2026-04-30 | Buy |
| Biosynth | CGC60802 | BAY1125976 | 1402608-02-9 | 5mg | $322.4 | 2026-06-04 | Buy |
BAY-1125976. Chemical Properties, Uses, Production
Description
BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.
Uses
BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
in vivo
BAY 1125976 targets tumors displaying activation of the PI3K/Akt/mTOR pathway. BAY 1125976 exhibits strong in vivo efficacy in both cell line and patient-derived xenograft models such as the KPL4 breast cancer model (PIK3CAH1074R mutant), the MCF7 and HBCx-2 breast cancer models, and the AktE17K mutant driven prostate cancer (LAPC-4) and anal cancer (AXF 984) models[1].
IC 50
Akt1: 5.2 nM (IC50, at 10 μM ATP); Akt2: 18 nM (IC50, at 10 μM ATP); Akt3: 427 nM (IC50, at 10 μM ATP)
References
[1] Politz O, et al. BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. Int J Cancer. 2017 Jan 15;140(2):449-459. DOI:10.1002/ijc.30457
BAY-1125976. Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2002 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
View Latest Price from BAY-1125976. manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-19 | BAY1125976
1402608-02-9
|
1KG | 98 | 1000 KG | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-07-27 | BAY1125976
1402608-02-9
|
$33.00-139.00 | 99.28% | 10g | TargetMol Chemicals Inc. |
-
- BAY1125976
1402608-02-9
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- BAY1125976
1402608-02-9
- $33.00-139.00
- 99.28%
- TargetMol Chemicals Inc.
