ChemicalBook >> CAS DataBase List >>5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
- CAS No.
- 1289646-93-0
- Chemical Name:
- 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
- Synonyms
- 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride;Lifitegrast Impurity 5;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride;lifitegrast-impurity IV-3;Lifitegrast Intermediate 2;Lifitegrast Impurity 18 HCl;Litakast Impurity 20 (hydrochloride);5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile HCl;6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydroc
- CBNumber:
- CB73137955
- Molecular Formula:
- C10H10Cl3NO2
- Molecular Weight:
- 282.55
- MDL Number:
- MFCD31556162
- MOL File:
- 1289646-93-0.mol
- MSDS File:
- SDS
Last updated:2026-05-28 03:45:55
| storage temp. | -20°C, sealed storage, away from moisture |
|---|---|
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C10H9Cl2NO2.ClH/c11-7-3-5-4-13-2-1-6(5)9(12)8(7)10(14)15;/h3,13H,1-2,4H2,(H,14,15);1H |
| InChIKey | CGXSFPJGZFRGNL-UHFFFAOYSA-N |
| SMILES | ClC1C(=C(Cl)C=C2CNCCC=12)C(=O)O.Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | D76167 | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic Acid Hydrochloride ≥95% | 1289646-93-0 | 250mg | $110 | 2026-05-06 | Buy |
| Synthonix | D76167 | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic Acid Hydrochloride ≥95% | 1289646-93-0 | 1g | $270 | 2026-05-06 | Buy |
| Synthonix | D76167 | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic Acid Hydrochloride ≥95% | 1289646-93-0 | 5g | $630 | 2026-05-06 | Buy |
| Synthonix | D76167 | 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic Acid Hydrochloride ≥95% | 1289646-93-0 | 10g | $980 | 2026-05-06 | Buy |
| aablocks | AA01LX5A | 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride 98% | 1289646-93-0 | 100mg | $53 | 2026-05-30 | Buy |
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Chemical Properties, Uses, Production
Uses
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) is a quinoline derivative used in pharmaceutical synthesis.
General Description
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride, also known as Lifitegrast Impurity 5, is an impurity of Lifitegrast. Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process.
Synthesis of 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride from 5,7-dichloro-2-trityl-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 106)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Dorher Pharmaceutical CO.,Ltd | 028-64259743 19983537320 | wangmin@focuspharm.com | China | 498 | 58 |
| BEIJING EAGLE SKY PHARMATECH CO., LTD | 010-88755821 13911359480;18612220856 | sophia_818@126.com | China | 299 | 55 |
| Chengdu Miracle Pharmaceutical Co., Ltd. | 028-86136736 19130631884 | sales@mic-pharma.com | China | 346 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. | 21-33585366 13311639313 | sales@shyrchem.com | China | 807 | 55 |
| Syncozymes (Shanghai) Co.,Ltd. | 021-68187180 13681683526 | lchen@syncozymes.com | China | 412 | 55 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai PharmOrgsyn Technology Co., LTD. | 021-+86-021-38228826 | sales@pharmorgsyn.cn | China | 250 | 58 |
| Shanghai Xiang Xin Industrial Co., Ltd. | 021-50211651 13651607026; | sales@xxgmpharm.com | China | 499 | 58 |
View Latest Price from 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-11 | Lifitegrast Impurity 5
1289646-93-0
|
10mg | 98.49% | 10g/month | Guangzhou Tosun Pharmaceutical Limited | ||
 |
2019-07-06 | Lifitegrast Intermediate 2
1289646-93-0
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- Lifitegrast Impurity 5
1289646-93-0
- 98.49%
- Guangzhou Tosun Pharmaceutical Limited
-
- Lifitegrast Intermediate 2
1289646-93-0
- $1.00
- 98%
- Career Henan Chemical Co
1289646-93-0 (5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride) Related Search:
Lifitegrast Impurity 6
Lifitegrast Impurity 3
Lifitegrast Impurity 9 HCl
Lifitegrast Impurity 8
2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-[[[(1S)-1-[[3-(methylsulfonyl)phenyl]methyl]-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl]-, 1,1-dimethylethyl ester
lifitegrast
benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate
(R)-Benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride
Ethyl benzofuran-6-carboxylate
L-Phenylalanine, N-[(5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3-(methylsulfonyl)-, phenylmethyl ester, hydrochloride (1:1)
1of3
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride
5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1
Lifitegrast Intermediate 2
5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1)
lifitegrast-impurity IV-3
6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...
Litakast Impurity 20 (hydrochloride)
6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydroc
Lifitegrast Impurity 18 HCl
Lifitegrast Impurity 5
5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid monohydrochloride
6-lsoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-. hydrochloride (1:1)
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile HCl
1289646-93-0
