SH5-07
- CAS No.
- 1456632-41-9
- Chemical Name:
- SH5-07
- Synonyms
- SH5-07;SH5-07 (SH-5-07);SH5-07, 10 mM in DMSO;Inhibitor,SH5-07,SH5 07,inhibit,STAT,SH507,SH-5-07;4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-N-hydroxybenzamide;Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-
- CBNumber:
- CB73147594
- Molecular Formula:
- C29H28F5N3O5S
- Molecular Weight:
- 625.61
- MDL Number:
- MFCD30718177
- MOL File:
- 1456632-41-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
SH5-07 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S283000 | SH5-07 | 1456632-41-9 | 2.5mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-6232 | SH5-07 >98.0% | 1456632-41-9 | 1mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-6232 | SH5-07 >98.0% | 1456632-41-9 | 5mg | $252 | 2021-12-16 | Buy |
| ChemScene | CS-6232 | SH5-07 >98.0% | 1456632-41-9 | 10mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-6232 | SH5-07 >98.0% | 1456632-41-9 | 50mg | $1800 | 2021-12-16 | Buy |
SH5-07 Chemical Properties,Uses,Production
Uses
SH5-?07 is a STAT3-inhibitor blocking the activation of signal transduction and subsequent activation of transcription 3 in chronic myeloid leukemia cell lines.
in vivo
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed[1].
IC 50
STAT3: 3.9 μM (IC50)
SH5-07 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
