SH-4-54
- CAS No.
- 1456632-40-8
- Chemical Name:
- SH-4-54
- Synonyms
- SH-4-54;CS-1773;SH-4-54 USP/EP/BP;SH-4-54, 10 mM in DMSO;STAT3/STAT5 Dual Inhibitor, SH-4-54;SH 4 54,Inhibitor,SH454,inhibit,STAT;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-benzoic acid;Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-;4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-Benzoic Acid SH-4-54
- CBNumber:
- CB92729656
- Molecular Formula:
- C29H27F5N2O5S
- Molecular Weight:
- 610.59
- MDL Number:
- MFCD28143917
- MOL File:
- 1456632-40-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 717.2±70.0 °C(Predicted) |
|---|---|
| Density | 1.431±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml |
| form | A crystalline solid |
| pka | 4.29±0.10(Predicted) |
| color | White to off-white |
| InChIKey | VFPYGNNOSJWBHF-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(C2=C(F)C(F)=C(F)C(F)=C2F)(=O)=O)=O)C=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
SH-4-54 price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.09105 | STAT3/STAT5 Dual Inhibitor, SH-4-54 | 1456632-40-8 | 10 mg | $247 | 2026-04-30 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 1456632-40-8 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 1456632-40-8 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 1456632-40-8 | 10mg | $219 | 2026-04-30 | Buy |
| Cayman Chemical | 25982 | SH-4-54 ≥98% | 1456632-40-8 | 25mg | $420 | 2026-04-30 | Buy |
SH-4-54 Chemical Properties, Uses, Production
Description
SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3; IC50 = 4.7 μM for STAT3 homodimer DNA binding activity). It selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5 and decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells. SH-4-54 inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively). In vivo, SH-4-54 (3 mg/kg per day) inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models.
Uses
4-[[(4-Cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]benzoic Acid acts as a STAT 3 and STAT5 inhibitor. STAT 3 is unusually active in glioblastoma and plays a crucial role in tumor growth
in vivo
SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors[1].
IC 50
STAT3: 300 nM (Kd); STAT5: 464 nM (Kd)
References
[1] PEIBIN YUE. Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.[J]. Cancer research, 2016, 76 3: 652-663. DOI: 10.1158/0008-5472.can-14-3558
SH-4-54 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Celes Technology Co., Ltd | 19982073091 | 2538834896@qq.com | China | 78 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4858 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3968 | 60 |
