2614W94
- CAS No.
- 205187-35-5
- Chemical Name:
- 2614W94
- Synonyms
- 2614W94;2614W-94,2614W94;2614W94, 10 mM in DMSO;3-(1,1,1-Trifluoropropan-2-yloxy)phenoxathiine 10,10-dioxide;Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide
- CBNumber:
- CB73175519
- Molecular Formula:
- C15H11F3O4S
- Molecular Weight:
- 344.31
- MDL Number:
- MFCD31382159
- MOL File:
- 205187-35-5.mol
2614W94 Chemical Properties,Uses,Production
Uses
2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate.
in vivo
2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg[1].
References
[1] Helen L. White, et al. Biochemical and Pharmacologic Properties of 2614W94, a Reversible, Competitive Inhibitor of MonoamineOxidase-A. DRUG DEVELOPMENT RESEARCH 45:1-9 (1998).
2614W94 Preparation Products And Raw materials
Raw materials
Preparation Products
2614W94 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |
View Lastest Price from 2614W94 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2025-10-09 | 2614W94
205187-35-5
|
US $78.00-260.00 / mg | 99.77% | 10g | TargetMol Chemicals Inc. | ||
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2025-10-09 | 2614W94
205187-35-5
|
US $78.00-260.00 / mg | 99.77% | 10g | TargetMol Chemicals Inc. | ||
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2025-05-09 | 2614W94
205187-35-5
|
US $91.00-260.00 / mg | 99.77% | 10g | TargetMol Chemicals Inc. |