AMG-747
- CAS No.
- 1000690-85-6
- Chemical Name:
- AMG-747
- Synonyms
- Tilapertin;AMG-747;1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-;(R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)piperazin-1-yl)acetic acid;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid
- CBNumber:
- CB73333708
- Molecular Formula:
- C20H21F3N2O2
- Molecular Weight:
- 378.39
- MDL Number:
- MFCD30532732
- MOL File:
- 1000690-85-6.mol
- MSDS File:
- SDS
| Boiling point | 455.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.276±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.24±0.10(Predicted) |
| FDA UNII | A2SV488G98 |
AMG-747 Chemical Properties, Uses, Production
Uses
Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
in vivo
Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].
IC 50
GlyT1
References
[1] Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. DOI:10.1016/j.schres.2016.10.027
AMG-747 Preparation Products And Raw materials
Raw materials
Preparation Products
AMG-747 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | dexuanyiyao@126.com | dexuanyiyao@126.com | China | 9470 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shandong Ziyi Pharmaceutical Co., Ltd. | 17860786593 | 1181917242@qq.com | China | 6937 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Latest Price from AMG-747 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Tilapertin
1000690-85-6
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Tilapertin
1000690-85-6
- $1520.00-2500.00
- TargetMol Chemicals Inc.
