| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
AMG-747 manufacturers
- Tilapertin
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- $2500.00
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2026-05-11
- CAS:1000690-85-6
- Purity:
- Supply Ability: 10g
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| | AMG-747 Basic information |
| Product Name: | AMG-747 | | Synonyms: | AMG-747;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid;1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-;Tilapertin;(R)-2-(4-(phenyl(3-(trifluoromethyl)phenyl)methyl)piperazin-1-yl)acetic acid | | CAS: | 1000690-85-6 | | MF: | C20H21F3N2O2 | | MW: | 378.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1000690-85-6.mol |  |
| | AMG-747 Chemical Properties |
| Boiling point | 455.3±45.0 °C(Predicted) | | density | 1.276±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.24±0.10(Predicted) |
| | AMG-747 Usage And Synthesis |
| Uses | Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1). | | in vivo | Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1]. | | IC 50 | GlyT1 | | References | [1] Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. DOI:10.1016/j.schres.2016.10.027 |
| | AMG-747 Preparation Products And Raw materials |
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