GSK-7975A
- CAS No.
- 1253186-56-9
- Chemical Name:
- GSK-7975A
- Synonyms
- GSK-7975A;CAS:1253186-56-9;GSK-7975A, 10 mM in DMSO;CRAC Channel Inhibitor IV, GSK-7975A;2,6-Difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide;Ca channels,Calcium Channel,GSK 7975A,inhibit,Inhibitor,Ca2+ channels,GSK7975A,GSK-7975A;2,6-Difluoro-N-(1-{[4-hydroxy-2-(trifluoromethyl)phenyl]methyl} 1H-pyrazol-3-yl)benzamide;Benzamide, 2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-yl]-
- CBNumber:
- CB73333733
- Molecular Formula:
- C18H12F5N3O2
- Molecular Weight:
- 397.3
- MDL Number:
- MFCD28411366
- MOL File:
- 1253186-56-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 462.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:90.0(Max Conc. mg/mL);226.53(Max Conc. mM) |
| pka | 8.82±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| InChI | 1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28) |
| InChIKey | CPYTVBALBFSXSH-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1c(ccc(c1)O)C[n]2nc(cc2)NC(=O)c3c(cccc3F)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
GSK-7975A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DAC18656 | GSK-7975A | 1253186-56-9 | 5mg | $250 | 2026-06-04 | Buy |
| Biosynth | DAC18656 | GSK-7975A | 1253186-56-9 | 10mg | $347.9 | 2026-06-04 | Buy |
| Biosynth | DAC18656 | GSK-7975A | 1253186-56-9 | 25mg | $652.25 | 2026-06-04 | Buy |
| Biosynth | DAC18656 | GSK-7975A | 1253186-56-9 | 50mg | $1043.5 | 2026-06-04 | Buy |
| Biosynth | DAC18656 | GSK-7975A | 1253186-56-9 | 100mg | $1671 | 2026-06-04 | Buy |
GSK-7975A Chemical Properties, Uses, Production
Uses
GSK-7975A is a potent and orally available CRAC channel inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
CRAC', 'Reversible: yes
in vivo
GSK-7975A inhibits local and systemic features of acute pancreatitis in TLCS-AP, CER-AP, FAEE-AP, in dose- and time-dependent manners. GSK-7975A significantly reduces increases in serum amylase, IL6, and pancreatic MPO levels; lung MPO is reduced significantly by low dose only. GSK-7975A markedly reduces pancreatic histopathology in TLCS-AP, CER-AP, and FAEE-AP[3].
References
[1] Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2. DOI:10.1016/j.jaci.2012.01.070
[2] Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. DOI:10.1016/j.ejphar.2013.02.022
[3] Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7. DOI:10.1053/j.gastro.2015.04.015
GSK-7975A Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-7975A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 499 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
