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Tropifexor

Tropifexor Structure
Tropifexor structure
CAS No.
1383816-29-2
Chemical Name:
Tropifexor
Synonyms
LJN452;CPD1549;CS-2712;LJP-305;Tropifexor;LJN452;CPD1549;LJN452,Tropifexor;Tropifexor (LJN452);LJN 452;LJN-452;LJN452;Tropifexor, 10 mM in DMSO
CBNumber:
CB73362023
Molecular Formula:
C29H25F4N3O5S
Molecular Weight:
603.59
MDL Number:
MFCD31619256
MOL File:
1383816-29-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Tropifexor ≥98% 25748 1mg $94
Tropifexor ≥98% 25748 5mg $164
Tropifexor 25748 500μg $93
Tropifexor BT166810 25mg $519.25
Tropifexor BT166810 50mg $649
More product size
Request For Quotation

Tropifexor Properties

Melting point 221 °C (triclinic crystal)
Boiling point 700.0±65.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:80.66(Max Conc. mg/mL);133.64(Max Conc. mM)
form A crystalline solid
pka 3.84±0.10(Predicted)
color Off-white to yellow
InChIKey VYLOOGHLKSNNEK-JWTNVVGKNA-N
SMILES S1C2=CC(C(O)=O)=CC(F)=C2N=C1N1[C@@]2([H])CC[C@]1([H])CC(OCC1=C(C3CC3)ON=C1C1=CC=CC=C1OC(F)(F)F)C2 |&1:14,18,r|
FDA UNII NMZ08KM76Z

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
NFPA 704
0
2 0

Tropifexor price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25748 Tropifexor ≥98% 1383816-29-2 1mg $94 2026-04-30 Buy
Cayman Chemical 25748 Tropifexor ≥98% 1383816-29-2 5mg $164 2026-04-30 Buy
Cayman Chemical 25748 Tropifexor 1383816-29-2 500μg $93 2024-03-01 Buy
Biosynth BT166810 Tropifexor 1383816-29-2 25mg $519.25 2026-06-04 Buy
Biosynth BT166810 Tropifexor 1383816-29-2 50mg $649 2026-06-04 Buy
Product number Packaging Price Buy
25748 1mg $94 Buy
25748 5mg $164 Buy
25748 500μg $93 Buy
BT166810 25mg $519.25 Buy
BT166810 50mg $649 Buy

Tropifexor Chemical Properties,Uses,Production

Uses

Tropifexor, is a highly potent non-bile acid FXR agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH).

in vivo

Tropifexor (compound 1) demonstrates highly potent induction of SHP and FGF15 in the ileum as doses as low as 0.1 mg/kg. In the liver, robust induction of SHP is observed at 0.01 mg/kg of Tropifexor with maximal levels of gene induction achieved at 0.3 mg/kg. Expression of CYP8B1 mRNA following 14 day treatment with Tropifexor is already apparent at the lowest dose (0.003 mg/kg), and CYP8B1 gene expression is fully repressed at doses above 0.03 mg/kg.Treatment of rats with Tropifexor exhibits a clear dose-dependent increase in plasma FGF15 protein, with maximal levels of FGF15 detected at 7 h postdose. Treatment with Tropifexor for 14 days produces a robust dose-dependent reduction in serum triglycerides and reaches a maximal response with a 0.3 mg/kg dose, resulting in a decrease of triglyceride levels to approximately 79% below the vehicle control group[1].

Tropifexor Preparation Products And Raw materials

Raw materials

Preparation Products

Tropifexor Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Chemia Biotechnology（Shanghai） Co., Ltd 		info@chemia-pharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
CR Corporation Limited 		fred.wen@crcorporation.cn China 8642 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Wuhan Godbullraw Chemical Co.,ltd 		+86-18986288449 Alisasales@godbullraw.com China 549 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Limited 		58
InvivoChem 		58
Wuhan Godbullraw Chemical Co.,ltd 		58

View Lastest Price from Tropifexor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tropifexor pictures 2026-07-27 Tropifexor
1383816-29-2
 $89.00-198.00 99.49% 10g TargetMol Chemicals Inc.
2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid pictures 2022-05-12 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
1383816-29-2
 10g 99.0% 10tons Wuhan Godbullraw Chemical Co.,ltd
3-benzothiazole-6-carboxylic acid pictures 2022-04-29 3-benzothiazole-6-carboxylic acid
1383816-29-2
 99% 1 tons Wuhan Godbullraw Chemical Co.,ltd
  • Tropifexor pictures
  • Tropifexor
    1383816-29-2
  • $89.00-198.00
  • 99.49%
  • TargetMol Chemicals Inc.

Tropifexor Spectrum

Tropifexor(1383816-29-2)1HNMR

1383816-29-2(Tropifexor)Related Search:

Tropifexor Ethanesulfonic acid, 2-[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1) Tauro Obeticholic acid Glyco Obeticholic acid LY-2562175
GW 4064

1of2

LJN 452;LJN-452;LJN452 CS-2712 CPD1549 Tropifexor Tropifexor (LJN452) LJN452,Tropifexor 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid 2-rel-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid LJN452;CPD1549 6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro- rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1 3-benzothiazole-6-carboxylic acid Tropifexor, 10 mM in DMSO LJP-305 Tropifexor (LJN452) ，S8733 2-((1r,3r,5s)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid LJN452 1383816-29-2 C29H25F4N3O5S API