Azido-PEG3-succinimidyl carbonate
- CAS No.
- 2110448-98-9
- Chemical Name:
- Azido-PEG3-succinimidyl carbonate
- Synonyms
- Azido-PEG3-O-NHS ester;Azido-PEG3-succinimidyl carbonate;2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl (2,5-Dioxopyrrolidin-1-yl) Carbonate
- CBNumber:
- CB73373568
- Molecular Formula:
- C13H20N4O8
- Molecular Weight:
- 360.3199
- MDL Number:
- MFCD31380406
- MOL File:
- 2110448-98-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H315-H319 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
Azido-PEG3-succinimidyl carbonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0115102 | Azido-PEG3-O-NHS ester ≥98% | 2110448-98-9 | 250mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0115102 | Azido-PEG3-O-NHS ester ≥98% | 2110448-98-9 | 500mg | $193572 | 2026-06-04 | Buy |
| BroadPharm | bp-23739 | Azido-PEG3-succinimidyl carbonate 95% | 2110448-98-9 | 100MG | $320 | 2026-05-24 | Buy |
| BroadPharm | bp-23739 | Azido-PEG3-succinimidyl carbonate 95% | 2110448-98-9 | 500MG | $650 | 2026-05-24 | Buy |
| BroadPharm | bp-23739 | Azido-PEG3-succinimidyl carbonate 95% | 2110448-98-9 | 1G | $950 | 2026-05-24 | Buy |
Azido-PEG3-succinimidyl carbonate Chemical Properties,Uses,Production
Description
Azido-PEG3-succinimidyl carbonate is a PEG linker that contains azide and succinimdyl carbonate moieties. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. The hydrophilic PEG linker increases the water solubility of the compound.
Uses
Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-O-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-succinimidyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG3-succinimidyl carbonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 3905209149@qq.com | China | 9716 | 58 |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 13892832556 | 2440688701@qq.com | China | 1977 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 770406999@qq.com | China | 9949 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39718 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9992 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | hanfangpharma@126.com 18017580634 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Yanfen Biochemical Technology Co.,LTD | 13611955358 15002190549 | yanfen2023@126.com | China | 2573 | 58 |
