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ChemicalBook >> CAS DataBase List >>(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Structure
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol structure
CAS No.
2040291-27-6
Chemical Name:
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
Synonyms
LLY-283;T15767;LM-5179;LLY-283 ，S8883;LLY-283 (LLY283);LLY-283 >=98% (HPLC);LLY-283, 10 mM in DMSO;7-[(5R)-5-CPhenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-;(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
CBNumber:
CB73373902
Molecular Formula:
C17H18N4O4
Molecular Weight:
342.35
MDL Number:
MFCD31657362
MOL File:
2040291-27-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-17 18:55:08
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(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Properties

Boiling point 688.9±55.0 °C(Predicted)
Density 1+-.0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 60 mg/ml; Ethanol: 60 mg/ml
form A crystalline solid
pka 12.46±0.70(Predicted)
color White to off-white
InChIKey WWOOWAHTEXIWBO-QFRSUPTLSA-N
SMILES O[C@@H]1[C@@H]([C@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1972 LLY-283 ≥98% (HPLC) 2040291-27-6 5 mg $246 2026-04-30 Buy
Sigma-Aldrich SML1972 LLY-283 ≥98% (HPLC) 2040291-27-6 25 mg $619 2026-04-30 Buy
Cayman Chemical 21596 LLY-283 ≥98% 2040291-27-6 1mg $36 2026-04-30 Buy
Cayman Chemical 21596 LLY-283 ≥98% 2040291-27-6 5mg $153 2026-04-30 Buy
Cayman Chemical 21596 LLY-283 ≥98% 2040291-27-6 10mg $268 2026-04-30 Buy
Product number Packaging Price Buy
SML1972 5 mg $246 Buy
SML1972 25 mg $619 Buy
21596 1mg $36 Buy
21596 5mg $153 Buy
21596 10mg $268 Buy

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Chemical Properties, Uses, Production

Description

LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 μM. It reduces symmetric demethylation of SmBB'' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. It also disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells and increases survival in an orthotopic patient-derived xenograft (PDX) mouse model. See the Structural Genomics Consortium (SGC) website for more information.

Uses

LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.

in vivo

LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days[1].

IC 50

PRMT5

References

[1] Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617.

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Suppliers

Global Suppliers ( 79)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Supplier Advantage
BOC Sciences 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghaizehan biopharma technology co., Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai SuperLan Chemcial Technique Centre 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Amadis Chemical Company Limited 58
Chuzhou KeMail Chemical Technology Co., Ltd 55

View Latest Price from (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol pictures 2026-07-17 (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
2040291-27-6
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
LLY-283 pictures 2026-07-14 LLY-283
2040291-27-6
 $34.00-79.00 99.22% 10g TargetMol Chemicals Inc.
  • LLY-283 pictures
  • LLY-283
    2040291-27-6
  • $34.00-79.00
  • 99.22%
  • TargetMol Chemicals Inc.

2040291-27-6 ((2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol) Related Search:

4-Amino-5-cyano-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 7-((3aR,4R,6R,6aR)-6-(aMinoMethyl)-2,2-diMethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 3'-Deoxytubercidin TUBERCIDIN 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-α-D-ribofuranosyl-
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(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol LM-5179 LLY-283 (LLY283) 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]- LLY-283 >=98% (HPLC) 7-[(5R)-5-CPhenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol LLY-283, 10 mM in DMSO T15767 LLY-283 ，S8883 LLY-283 2040291-27-6