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5-Chloro-1-methylimidazole

5-Chloro-1-methylimidazole Structure
5-Chloro-1-methylimidazole structure
CAS No.
872-49-1
Chemical Name:
5-Chloro-1-methylimidazole
Synonyms
TIMTEC-BB SBB004296;5-Chloro-1-methylimidazde;5-CHLORO-1-METHYLIMIDAZOLE;1-METHYL-5-CHLOROIMIDAZOLE;5-Chloro-1-methylimidazole,98%;5-CHLORO-1-METHYL-1H-IMIDAZOLE;5-Chloro-1-methylimidazole >5-Chloro-1-MethyliMidazole-13C4;1H-Imidazole, 5-chloro-1-methyl-;-13C4 1-Methyl-5-chloroiMidazole-13C4
CBNumber:
CB7344637
Molecular Formula:
C4H5ClN2
Molecular Weight:
116.55
MDL Number:
MFCD00014505
MOL File:
872-49-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:25:41
Request For Quotation

5-Chloro-1-methylimidazole Properties

Melting point 82-85°C(11 mmHg)
Boiling point 82-85 °C/11 mmHg (lit.)
Density 1.25 g/mL at 25 °C (lit.)
refractive index n20/D 1.511(lit.)
Flash point 205 °F
storage temp. Sealed in dry,Room Temperature
solubility Soluble in chloroform and insoluble in water
pka 5.31±0.10(Predicted)
form Oil
color Colorless to yellow to brown liquid
Water Solubility insoluble
BRN 110509
InChI InChI=1S/C4H5ClN2/c1-7-3-6-2-4(7)5/h2-3H,1H3
InChIKey NYDGOZPYEABERA-UHFFFAOYSA-N
SMILES C1N(C)C(Cl)=CN=1
CAS DataBase Reference 872-49-1(CAS DataBase Reference)
NIST Chemistry Reference 5-Chloro-1-methylimidazole(872-49-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933299090
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

5-Chloro-1-methylimidazole price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 330205 5-Chloro-1-methylimidazole 98% 872-49-1 1g $109 2026-04-30 Buy
TCI Chemical C2317 5-Chloro-1-methylimidazole >98.0%(GC)(T) 872-49-1 5g $47 2026-04-30 Buy
TCI Chemical C2317 5-Chloro-1-methylimidazole >98.0%(GC)(T) 872-49-1 25g $142 2026-04-30 Buy
TRC TRC-C369185-5G 5-Chloro-1-methylimidazole 872-49-1 5g $376 2026-06-03 Buy
TRC TRC-C369185-2G 5-Chloro-1-methylimidazole 872-49-1 2g $179 2026-06-03 Buy
Product number Packaging Price Buy
330205 1g $109 Buy
C2317 5g $47 Buy
C2317 25g $142 Buy
TRC-C369185-5G 5g $376 Buy
TRC-C369185-2G 2g $179 Buy

5-Chloro-1-methylimidazole Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Oil

Uses

5-Chloro-1-methylimidazole is a labelled useful synthetic intermediate.

Uses

A useful synthetic intermediate.

General Description

5-Chloro-1-methylimidazole is a 5-halo-1-methylimidazole. It participates in electron-rich iron(III) porphyrin complex catalyzed epoxidation of olefins.

Synthesis

N,N'-Dimethyloxamide

615-35-0

5-Chloro-1-methylimidazole

872-49-1

The general procedure for the synthesis of 5-chloro-1-methylimidazole from N,N'-dimethyl oxalamide was as follows: phosphorus pentachloride (383.2 g, 1.8 mol) was added to N,N'-dimethyl oxalamide (116.1 g, 1.0 mol), and heated to 60 °C to form a melt with foam generation. Subsequently, the reaction mixture was stirred at 85-95 °C for 2 h, and then distilled to remove the resulting POCl3. The dark brown residue was dissolved in 700 mL of water and adjusted to pH 8 with 915 g of 12.75% KOH solution. The aqueous phase was extracted four times with 500 mL of dichloromethane (DCM), and the organic extracts were combined and dried over sodium sulfate. After concentration under reduced pressure, the resulting reddish brown liquid was vacuum distilled to give 5-chloro-1-methylimidazole (53.1 g, 46% yield) as a colorless liquid. The product properties were as follows: flash point 85-86 °C (22 mbar); 1H NMR (400 MHz, d6-DMSO) δ 7.33 (s, 1H, 4-H), 6.80 (s, 1H, 2-H), 3.47 (s, 3H, CH3); 13C NMR (100 MHz, d6-DMSO) δ 137.4 (C-2), 126.0 (C -4), 118.4 (C-5), 31.6 (CH3).

References

[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 5, p. 391 - 396
[2] Patent: US2017/281501, 2017, A1. Location in patent: Paragraph 0272-0276
[3] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1047 - 1060
[4] Archiv der Pharmazie, 1988, vol. 321, # 4, p. 193 - 197
[5] Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2690 - 2695

5-Chloro-1-methylimidazole Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride Phosphorus pentachloride N,N'-Dimethyloxamide Dimethylamine

Preparation Products

Azathioprine 5-Chloro-1-methyl-4-nitroimidazole

5-Chloro-1-methylimidazole Suppliers

Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiaxing Deyi Chemical Co., Ltd 0573-85866609 13325730825 jiaxingshidy@163.com China 7898 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Jiaxing Deyi Chemical Co., Ltd 58
Shanghai Topbiochem Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Lastest Price from 5-Chloro-1-methylimidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Chloro-1-methylimidazole pictures 2026-06-30 5-Chloro-1-methylimidazole
872-49-1
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
5-Chloro-1-methylimidazole pictures 2019-07-06 5-Chloro-1-methylimidazole
872-49-1
 $2.00 1KG 98% 1ton Career Henan Chemical Co

5-Chloro-1-methylimidazole Spectrum

5-Chloro-1-methylimidazole(872-49-1)1HNMR5-Chloro-1-methylimidazole(872-49-1)IR5-Chloro-1-methylimidazole(872-49-1)FT-IR5-Chloro-1-methylimidazole(872-49-1)Raman

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TIMTEC-BB SBB004296 1H-Imidazole, 5-chloro-1-methyl- 5-CHLORO-1-METHYLIMIDAZOLE 5-CHLORO-1-METHYL-1H-IMIDAZOLE 1-METHYL-5-CHLOROIMIDAZOLE 2-[(3-methylphenyl)thio]-1H-quinazolin-4-one 5-Chloro-1-methylimidazde 5-Chloro-1-MethylImidazole(ForAzathiopurine) 5-Chloro-1-methylimidazole,98% -13C4 1-Methyl-5-chloroiMidazole-13C4 5-Chloro-1-MethyliMidazole-13C4 5-Chloro-1-methylimidazole > 872-49-1 C4H5N2Cl C4H5ClN2 Building Blocks Imidazoles Heterocyclic Building Blocks Halogenated Heterocycles Heterocycles Intermediates Halogenated Heterocycles Heterocyclic Building Blocks Imidazoles ImidazolesBuilding Blocks Building Blocks Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocycles series Imidazol&Benzimidazole Imidaxoles