5-Chloro-1-methylimidazole
- CAS No.
- 872-49-1
- Chemical Name:
- 5-Chloro-1-methylimidazole
- Synonyms
- TIMTEC-BB SBB004296;5-Chloro-1-methylimidazde;5-CHLORO-1-METHYLIMIDAZOLE;1-METHYL-5-CHLOROIMIDAZOLE;5-Chloro-1-methylimidazole,98%;5-CHLORO-1-METHYL-1H-IMIDAZOLE;5-Chloro-1-methylimidazole >5-Chloro-1-MethyliMidazole-13C4;1H-Imidazole, 5-chloro-1-methyl-;-13C4 1-Methyl-5-chloroiMidazole-13C4
- CBNumber:
- CB7344637
- Molecular Formula:
- C4H5ClN2
- Molecular Weight:
- 116.55
- MDL Number:
- MFCD00014505
- MOL File:
- 872-49-1.mol
- MSDS File:
- SDS
| Melting point | 82-85°C(11 mmHg) |
|---|---|
| Boiling point | 82-85 °C/11 mmHg (lit.) |
| Density | 1.25 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 205 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in chloroform and insoluble in water |
| pka | 5.31±0.10(Predicted) |
| form | Oil |
| color | Colorless to yellow to brown liquid |
| Water Solubility | insoluble |
| BRN | 110509 |
| InChI | InChI=1S/C4H5ClN2/c1-7-3-6-2-4(7)5/h2-3H,1H3 |
| InChIKey | NYDGOZPYEABERA-UHFFFAOYSA-N |
| SMILES | C1N(C)C(Cl)=CN=1 |
| CAS DataBase Reference | 872-49-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Chloro-1-methylimidazole(872-49-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933299090 | |||||||||
| NFPA 704 |
|
5-Chloro-1-methylimidazole price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 330205 | 5-Chloro-1-methylimidazole 98% | 872-49-1 | 1g | $81.4 | 2025-07-31 | Buy |
| TCI Chemical | C2317 | 5-Chloro-1-methylimidazole >98.0%(GC)(T) | 872-49-1 | 5g | $59 | 2025-07-31 | Buy |
| TCI Chemical | C2317 | 5-Chloro-1-methylimidazole >98.0%(GC)(T) | 872-49-1 | 25g | $178 | 2025-07-31 | Buy |
| TRC | C369185 | 5-Chloro-1-methylimidazole | 872-49-1 | 1g | $75 | 2021-12-16 | Buy |
| TRC | C369185 | 5-Chloro-1-methylimidazole | 872-49-1 | 5g | $295 | 2021-12-16 | Buy |
5-Chloro-1-methylimidazole Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Oil
Uses
5-Chloro-1-methylimidazole is a labelled useful synthetic intermediate.
Uses
A useful synthetic intermediate.
General Description
5-Chloro-1-methylimidazole is a 5-halo-1-methylimidazole. It participates in electron-rich iron(III) porphyrin complex catalyzed epoxidation of olefins.
Synthesis
615-35-0
872-49-1
The general procedure for the synthesis of 5-chloro-1-methylimidazole from N,N'-dimethyl oxalamide was as follows: phosphorus pentachloride (383.2 g, 1.8 mol) was added to N,N'-dimethyl oxalamide (116.1 g, 1.0 mol), and heated to 60 °C to form a melt with foam generation. Subsequently, the reaction mixture was stirred at 85-95 °C for 2 h, and then distilled to remove the resulting POCl3. The dark brown residue was dissolved in 700 mL of water and adjusted to pH 8 with 915 g of 12.75% KOH solution. The aqueous phase was extracted four times with 500 mL of dichloromethane (DCM), and the organic extracts were combined and dried over sodium sulfate. After concentration under reduced pressure, the resulting reddish brown liquid was vacuum distilled to give 5-chloro-1-methylimidazole (53.1 g, 46% yield) as a colorless liquid. The product properties were as follows: flash point 85-86 °C (22 mbar); 1H NMR (400 MHz, d6-DMSO) δ 7.33 (s, 1H, 4-H), 6.80 (s, 1H, 2-H), 3.47 (s, 3H, CH3); 13C NMR (100 MHz, d6-DMSO) δ 137.4 (C-2), 126.0 (C -4), 118.4 (C-5), 31.6 (CH3).
References
[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 5, p. 391 - 396
[2] Patent: US2017/281501, 2017, A1. Location in patent: Paragraph 0272-0276
[3] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1047 - 1060
[4] Archiv der Pharmazie, 1988, vol. 321, # 4, p. 193 - 197
[5] Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2690 - 2695
5-Chloro-1-methylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2953 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 5-Chloro-1-methylimidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-25 | 5-Chloro-1-methylimidazole
872-49-1
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2019-07-06 | 5-Chloro-1-methylimidazole
872-49-1
|
US $2.00 / KG | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 5-Chloro-1-methylimidazole
872-49-1
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Chloro-1-methylimidazole
872-49-1
- US $2.00 / KG
- 98%
- Career Henan Chemical Co
