1,2-Diamino-3,5-difluorobenzene
- CAS No.
- 2369-29-1
- Chemical Name:
- 1,2-Diamino-3,5-difluorobenzene
- Synonyms
- 3,5-Difluorobenzene-1,2-diamine;BUTTPARK 19\01-53;1,2-Diamino-3,5-difluorobenzene;3,5-DIFLUORO-1,2-PHENYLENEDIAMINE;1,2-Benzenediamine, 3,5-difluoro-;3,5-Difluorophenylene-1,2-diamine, 1,2-Diamino-3,5-difluorobenzene
- CBNumber:
- CB7347269
- Molecular Formula:
- C6H6F2N2
- Molecular Weight:
- 144.12
- MDL Number:
- MFCD00973899
- MOL File:
- 2369-29-1.mol
- MSDS File:
- SDS
| Melting point | 48.5-49.5℃ |
|---|---|
| Boiling point | 246.1±35.0 °C(Predicted) |
| Density | 1.407±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | crystalline solid |
| pka | 2.83±0.10(Predicted) |
| color | White to dark brown two-tone |
| InChI | 1S/C6H6F2N2/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,9-10H2 |
| InChIKey | QGNXDMSEEPNKCF-UHFFFAOYSA-N |
| SMILES | Nc1cc(F)cc(F)c1N |
| CAS DataBase Reference | 2369-29-1(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HS Code | 2921599090 |
| Storage Class | 11 - Combustible Solids |
1,2-Diamino-3,5-difluorobenzene price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS010697 | 1,2-diamino-3,5-difluorobenzene AldrichCPR | 2369-29-1 | 250MG | $77.9 | 2026-04-30 | Buy |
| Apolloscientific | PC0143 | 3,5-Difluorobenzene-1,2-diamine ≥95% | 2369-29-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC0143 | 3,5-Difluorobenzene-1,2-diamine ≥95% | 2369-29-1 | 5g | $82 | 2026-06-04 | Buy |
| Apolloscientific | PC0143 | 3,5-Difluorobenzene-1,2-diamine ≥95% | 2369-29-1 | 25g | $301 | 2026-06-04 | Buy |
| Activate Scientific | AS49179 | 3,5-Difluorobenzene-1,2-diamine 98% | 2369-29-1 | 1g | $30 | 2026-06-04 | Buy |
1,2-Diamino-3,5-difluorobenzene Chemical Properties, Uses, Production
Synthesis
364-30-7
2369-29-1
General procedure for the synthesis of 3,5-difluoro-1,2-phenylenediamine from 2,4-difluoro-6-nitroaniline: concentrated hydrochloric acid (10 mL) was slowly added dropwise to a mixture of 2,4-difluoro-6-nitroaniline (1.6 g, 9 mmol) and tin powder (22.5 mmol). The reaction mixture was heated to reflux for 1.5 h, subsequently cooled to room temperature and neutralized with 50% NaOH solution to pH 9-10. The precipitate was collected by filtration, dried and extracted with hot ethyl acetate (80 mL). The filtrate was subjected to secondary evaporation to give 3,5-difluoro-1,2-benzenediamine. Yield: 0.60 g (46%); the product was brown crystals; melting point 55-57 °C; Rf value was 0.86.
References
[1] Tetrahedron Letters, 2006, vol. 47, # 27, p. 4591 - 4595
[2] European Journal of Medicinal Chemistry, 2009, vol. 44, # 7, p. 2930 - 2935
[3] Synthesis (Germany), 2016, vol. 48, # 3, p. 394 - 406
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 153
[5] Journal of the American Chemical Society, 1959, vol. 81, p. 94,98
1,2-Diamino-3,5-difluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
View Latest Price from 1,2-Diamino-3,5-difluorobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-22 | 1,2-DIAMINO-3,5-DIFLUOROBENZENE
2369-29-1
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-12 | 1,2-DIAMINO-3,5-DIFLUOROBENZENE
2369-29-1
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 1,2-DIAMINO-3,5-DIFLUOROBENZENE
2369-29-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1,2-DIAMINO-3,5-DIFLUOROBENZENE
2369-29-1
- $1.00
- 99%
- Career Henan Chemical Co
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