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ChemicalBook >> CAS DataBase List >>11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Structure
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione structure
CAS No.
13951-70-7
Chemical Name:
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms
(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16α-hydroxy-prednisolone;Budesonide EP Impurity A;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3
CBNumber:
CB7352308
Molecular Formula:
C21H28O6
Molecular Weight:
376.44
MDL Number:
MFCD00872019
MOL File:
13951-70-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-20 23:19:27
Product description Number Pack Size Price
16α-hydroxy Prednisolone ≥98% 27169 1g $36
16α-hydroxy Prednisolone ≥98% 27169 5g $153
16α-hydroxy Prednisolone ≥98% 27169 10g $268
16α-hydroxy Prednisolone ≥98% 27169 25g $527
11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione (16a-hydroxyprednisolone) T2972-14 50mg $453
More product size
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Properties

Melting point 235-238°C
Boiling point 591.5±50.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka 11.93±0.70(Predicted)
color White to Light Yellow
Water Solubility 815mg/L at 20℃
Major Application pharmaceutical
InChIKey SEKYBDYVXDAYPY-WVOWJGHQNA-N
SMILES [C@@]12([H])C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@]1([H])[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H] |&1:0,3,5,11,14,16,18,28,r|
LogP 0.8 at 25℃
CAS DataBase Reference 13951-70-7(CAS DataBase Reference)
FDA UNII SW97540DC2
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501
WGK Germany  WGK 3
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B
REACH Registrations Active

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27169 16α-hydroxy Prednisolone ≥98% 13951-70-7 1g $36 2026-04-30 Buy
Cayman Chemical 27169 16α-hydroxy Prednisolone ≥98% 13951-70-7 5g $153 2026-04-30 Buy
Cayman Chemical 27169 16α-hydroxy Prednisolone ≥98% 13951-70-7 10g $268 2026-04-30 Buy
Cayman Chemical 27169 16α-hydroxy Prednisolone ≥98% 13951-70-7 25g $527 2026-04-30 Buy
Usbiological T2972-14 11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione (16a-hydroxyprednisolone) 13951-70-7 50mg $453 2026-06-04 Buy
Product number Packaging Price Buy
27169 1g $36 Buy
27169 5g $153 Buy
27169 10g $268 Buy
27169 25g $527 Buy
T2972-14 50mg $453 Buy

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

References

[1] Patent: WO2016/120891, 2016, A1. Location in patent: Page/Page column 13; 14

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione synthesis

86401-80-1
13951-70-7
Synthesis of 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione from 16alpha-Hydroxyprednisonlone acetate

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Methanol Sodium hydroxide 112,21-dihydroxypregna-1,4,16-triene-3,20-dione Dichloromethane 16alpha-Hydroxyprednisonlone acetate

Preparation Products

Desonide

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

Global( 366)Suppliers
Supplier Tel Email Country ProdList Advantage
BIONNA MEDICINE CO.,LTD
01056380788-8515; +8618518759099 790226113@qq.com China 52 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +86-15383190639 admin@86-ss.com China 992 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21189 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6361 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14320 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
Supplier Advantage
BIONNA MEDICINE CO.,LTD
58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Accela ChemBio Inc. 		58
Xiamen AmoyChem Co., Ltd 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58

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View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione pictures 2026-08-11 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
13951-70-7
 $75.00-100.00 1kg 99% 5000Ton HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
16α-Hydroxyprednisolone pictures 2026-07-20 16α-Hydroxyprednisolone
13951-70-7
 $30.00 99.97% 10g TargetMol Chemicals Inc.
11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione pictures 2026-07-15 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
13951-70-7
 $2460.00 500g 99% 10000KG Baoji Guokang Healthchem Co., Ltd.

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Spectrum

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione(13951-70-7)1HNMR

13951-70-7(11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione)Related Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide
Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide
(r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide

1of4

16A-HYDROXY-PREDNISONLONE 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16 Alpha Hydroxprednisolone 11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione Einecs 237-731-1 16-ALPHA-HYDROXY PREDNISOLONE 16A-HYDROXY-PREDNISOLONE 11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16a-Hydroxypredisolone (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16α-Hydroxyprednisolon Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone) (8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione 9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid Budesonide iMpurit A Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone) BNKY015-BD04 16α-hydroxy-prednisolone 16b 20-dione 21-Tetrahydroxy-pregna-1 4-diene-3 Budesonide impurity A Budesonide Impurity 1(Budesonide EP Impurity A) 11beta,16alpha,17,21-Tetrahydroxypr Desonide Impurity A Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)- 16α-hydroxy Prednisolone 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP Tmo Trimethylamine N-Oxide Dihydrate Powder 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone) 16α-hydroxy-prednisonlone 16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone 16α-Hydroxyprednisolone-d5 16α-Hydroxyprednisolone (Budesonide Impurity) 16α-Hydroeyprednisolone 11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione 11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one Desonide EP Impurity-A 16α-Hydroxyprednisolone/11β,16β,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione (16alpha-Hydroxyprednisolone) 16α-Hydroxyprednisolone, 10 mM in DMSO 11?,16a,17,21-Tetrahydroxypregna-1,4-dien-3,20-dione 11β,16α,17,21-Tetrahydroxypregna-1,4-dien-3,20-dione 11a'16b'17'21-Tetrahydroxy-pregna-1 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione 16alpha-Hydroxyprednisolone (11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione) 16α-Hydroxprednisolone Budesonide USP Impurity A 16α-Hydroxyprednisolone (Standard) (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione Budesonide EP Impurity A