3,4-Dimethoxy-2'-hydroxychalcone
- CAS No.
- 19152-36-4
- Chemical Name:
- 3,4-Dimethoxy-2'-hydroxychalcone
- Synonyms
- 2'-HYDROXY-3,4-DIMETHOXYCHALCONE;3,4-Dimethoxy-2'-hydroxychalcone;2''-Hydroxy-3,4-dimethoxychalcone;3-(3,4-DIMETHOXYPHENYL)-1-(2-HYDROXYPHENYL)PROP-2-EN-1-ONE;2-Propen-1-one, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-;3-(3,4-Dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one , 2'-Hydroxy-3,4-dimethoxychalcone
- CBNumber:
- CB7378205
- Molecular Formula:
- C17H16O4
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD00017630
- MOL File:
- 19152-36-4.mol
- MSDS File:
- SDS
| Melting point | 113 - 115°C |
|---|---|
| Boiling point | 466.4±45.0 °C(Predicted) |
| Density | 1.203±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 7.67±0.30(Predicted) |
| color | Yellow to Orange |
| Stability | Light Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2914409000 | |||||||||
| NFPA 704 |
|
3,4-Dimethoxy-2'-hydroxychalcone price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-H296895-500MG | 2'-Hydroxy-3,4-dimethoxychalcone | 19152-36-4 | 500mg | $175 | 2026-06-03 | Buy |
| TRC | TRC-H296895-1G | 2'-Hydroxy-3,4-dimethoxychalcone | 19152-36-4 | 1g | $249 | 2026-06-03 | Buy |
| Biosynth | FH66765 | 2'-Hydroxy-3,4-dimethoxychalcone | 19152-36-4 | 5g | $797.5 | 2026-06-04 | Buy |
| Biosynth | FH66765 | 2'-Hydroxy-3,4-dimethoxychalcone | 19152-36-4 | 10g | $1435.5 | 2026-06-04 | Buy |
| Apolloscientific | OR27800 | 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 95% | 19152-36-4 | 1g | $85 | 2026-06-04 | Buy |
3,4-Dimethoxy-2'-hydroxychalcone Chemical Properties,Uses,Production
Uses
2''-Hydroxy-3,4-dimethoxychalcone, is a building block used in various chemical synthesis such as in the synthesis of new flavanoid and chalcone derivatives as antimicrobial agent by green chemistry approach.
Synthesis
118-93-4
120-14-9
79140-20-8
The method is applicable to compounds that do not contain free phenolic hydroxyl groups or when the phenolic hydroxyl groups are protected as methyl or benzyl ethers. The corresponding 2'-hydroxyacetophenone (10 mmol) was dissolved in anhydrous THF (25 mL), and NaH (25 mmol, 1 g 60% mineral oil dispersion) was added to the solution in batches under nitrogen protection with vigorous stirring. After the hydrogen release ceased, a corresponding solution of anhydrous THF (25 mL) with veratraldehyde (10 mmol) was added slowly and dropwise over a period of 15 minutes, followed by stirring of the reaction mixture at room temperature for 16 hours (unless otherwise indicated). Upon completion of the reaction, the mixture was carefully poured into ice water (100 mL) to quench the excess NaH and stirred until the hydrogen release stopped completely. The mixture was acidified with 25% HCl and subsequently extracted with ethyl acetate (3 x 50 mL). The organic layers were combined and washed sequentially with water (3 x 50 mL) and brine (50 mL) and then dried with anhydrous MgSO4. The solution was concentrated under reduced pressure to 1/3 of the original volume at 40 °C, then cooled at 0 °C for 12 h. The crystalline product was collected by filtration. The purity of 2'-hydroxychalcone obtained in this way is sufficient for most applications. Analytically pure samples require further purification by column chromatography. Good yields of chalcone can be obtained by this method. Additional product can be obtained by evaporating the solvent from the mother liquor and purifying by column chromatography.
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3060 - 3073
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 17, p. 4241 - 4245
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 9, p. 1311 - 1314
[4] Biocatalysis and Biotransformation, 2013, vol. 31, # 4, p. 160 - 167
[5] Chemische Berichte, 1905, vol. 38, p. 2178
3,4-Dimethoxy-2'-hydroxychalcone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
3,4-Dimethoxy-2'-hydroxychalcone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING TDVINO TECHNOLOGY CO.,LTD | 010-56371379 | China | 99 | 55 | |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| sgtlifesciences pvt ltd | +91-8790379245 | dj@sgtlifesciences.com | China | 12351 | 58 |
| NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 | CHINA | 2028 | 58 | |
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1340 | 58 |
| Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. | 15990591583 | China | 6129 | 58 |
View Lastest Price from 3,4-Dimethoxy-2'-hydroxychalcone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-04 | 2'-Hydroxy-3,4-dimethoxychalcone
19152-36-4
|
$50.00 | 98.04% | 10g | TargetMol Chemicals Inc. |
-
- 2'-Hydroxy-3,4-dimethoxychalcone
19152-36-4
- $50.00
- 98.04%
- TargetMol Chemicals Inc.
19152-36-4(3,4-Dimethoxy-2'-hydroxychalcone)Related Search:
1of4
